研究内容
- 食品益生菌或菌群的筛选、改造和应用
- 细胞代谢、细胞衰老的机理性研究
论文
- 1. Phase separation modulates the assembly and dynamics of a polarity-related scaffold-signaling hub. W. Tan#, S. Cheng#, Y. Li#, N. Lu, J. Sun, G. Tang, Y. Yang, K. Cai, X. Ou, X. Gao, G-P. Zhao, W.S. Childers, W. Zhao*. Nature Communications 13:7181. 2022
- 2. A CRISPR-SpCas9M-reporting system for efficient and rapid genome editing in Caulobacter crescentus. J. Sun#, X. Yu#, G. Tang, M. Chen, Y. Zheng, Y. Hu, Q. Li, X. Li, N. Li, Z. Li, Y. Li, N. Lu, W. Tan, Y. Yang, X. Lyu, G. Zhao, H. Wang, L. Dai, G-P. Zhao, L. Ai*, W. Zhao*. Nucleic Acids Research 53(8). 2025
- 3. Deacetylation enhances ParB-DNA interactions affecting chromosome segregation in Streptomyces coelicolor. P. Li, H. Zhang, G-P. Zhao*, W. Zhao*. Nucleic Acids Research 48(9):4902-4914. 2020
- 4. Structural basis of three different transcription activation strategies adopted by a single regulator SoxS. J. Shi#,*, L. Wang#, A. Wen#, F. Wang#, Y. Zhang, L. Yu, F. Li, Y. Jin, Z. Feng, J. Li, Y. Yang, F. Gao, Y. Zhang, Y. Feng*, S. Wang*, W. Zhao*, W. Lin*. Nucleic Acids Research 50(19):11359–11373. 2022
- 5. Scaffold-scaffold interaction facilitates cell polarity development in Caulobacter crescentus. N. Lu#, S.W. Duvall#, G. Zhao, K.A. Kowallis, C. Zhang, W. Tan, J. Sun, H.N. Petitjean, D.T. Tomares, G-P. Zhao, W.S. Childers*, W. Zhao*. mBio 14 (2), e03218-22, 2023
- 6. Global insights into lysine acylomes reveal crosstalk between lysine acetylation and succinylation in Streptomyces coelicolor metabolic pathways. Y. Yang#, H. Zhang#, Z. Guo, S. Zou, F. Long, J. Wu, P. Li*, G-P. Zhao*, W. Zhao*. Molecular & Cellular Proteomics 20, 100148. 2021
- 7. ScCobB2-mediated lysine desuccinylation regulates protein biosynthesis and carbon metabolism in Streptomyces coelicolor. H. Zhang, P. Li, S. X. Ren, Z. Y. Chen, G-P. Zhao*, W. Zhao*. Molecular & Cellular Proteomics 18(10):2003-2017. 2019
- 8. Recent advances in the synthesis and application of biomolecular condensates. Z. Li, W. Tan, G-P. Zhao, X. Zeng*, W. Zhao*. Journal of Biological Chemistry 108188, 2025
- 9. Zymograph profiling reveals a divergent evolution of sirtuin that may originate from Class III enzymes. Y. Yang#, S. Zou#, K. Cai, N. Li, Z. Li, W. Tan, W. Lin*, GP. Zhao*, W. Zhao*. Journal of Biological Chemistry 105339. 2023
- 10. Cyclic AMP inhibits the activity and promotes the acetylation of acetyl-CoA synthetase through competitive binding to the ATP/AMP pocket. X.B. Han#, L.Q. Shen#, Q. Wang, X. Cen, J. Wang, M. Wu, P. Li, W. Zhao*, Y. Zhang* and G-P. Zhao*. Journal of Biological Chemistry 292:1374-1384. 2017
- 11. RT-RPA-Cas12a-based assay facilitates the discrimination of SARS-CoV-2 variants of concern. G. Tang#, Z. Zhang#, W. Tan#, F. Long, J. Sun, Y. Li, S. Zou, Y. Yang, K. Cai, S. Li, Z. Wang, J. Liu, G. Mao, Y. Ma, G-P. Zhao*, Z-G. Tian*, W. Zhao*. Sensors and Actuators B: Chemical 381, 133433, 2023
- 12. Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis. L. Xu#, H. Huang#, W. Wei#, Y. Zhong, B. Tang, H. Yuan, L. Zhu, W. Huang, M. Ge, S. Yang, H. Zheng, W. Jiang*, D. Chen*, G-P. Zhao*, W. Zhao*. BMC Genomics 15:363. 2014
- 13. Spatiotemporal Control of Liquid–Liquid Phase Separation for Advanced Biomanufacturing. Y. Li#, C. Zeng#, X. Lyu, W. Tan, W. Zhao*. ACS Synthetic Biology 14 (11), 4255-4265. 2025
- 14. Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. W. Zhao#, Y. Zhong#, H. Yuan#, J. Wang#, H. Zheng, Y. Wang, X. Cen, F. Xu, J. Bai, X. Han, G. Lu, Y. Zhu, Z. Shao, H. Yan, C. Li, N. Peng, Z. Zhang, Y. Zhang, W. Lin, Y. Fan, Z. Qin, Y. Hu, B. Zhu, S. Wang*, X. Ding*, G-P. Zhao*. Cell Research 20:1096-1108. 2010
- 15. Unraveling Enzyme-Substrate Dynamics in Protein Acylation and Disease Implications. S. Cheng, T. Liu, J. Xing, G. Zhang, L. Zhang*, W. Zhao*. Frontiers in Molecular Biosciences 13, 1842734. 2026