首页 师资队伍 教师名录 张文灿
PI
张文灿 长聘教轨副教授
农生学院A楼3-405 wenczhang@sjtu.edu.cn
张文灿，上海交通大学农业与生物学院长聘教轨副教授，博士生导师，课题组组长（独立PI），入选2023年上海市海外高层次人才。2019年博士毕业于新加坡国立大学（National University of Singapore），2019-2023年于美国希望之城国家医学中心 (City of Hope National Medical Center) 从事博士后研究。2024年1月加入上海交通大学。长期聚焦免疫学、分子生物学及食品科学，具有突出的多学科研究背景。共发表SCI论文18篇，其中第一作者文章12篇，包括PNAS，Science Advances，Food Research International等。课题组聚焦动物科学与免疫调控，研究方向涉及1）病原微生物与适应性免疫系统的互作机制; 2) T细胞的分化调控及其介导的免疫响应；3）家畜炎性疾病的发病机理及药物研制。 欢迎对T细胞免疫调控及动物科学感兴趣的本科生、研究生及博士后咨询、加盟。
教育经历
  • 1970-1970，新加坡国立大学，博士
工作经历
  • 1970-至今，美国希望之城国家医学中心，博士后
  • 1970-至今，上海交通大学农业与生物学院，副教授、博士生导师
研究内容
  • 病原微生物与适应性免疫系统的互作机制
  • T细胞的分化调控及其介导的免疫响应
论文
  • Zhang, W., Cao, X., Zhong, X., Wu, H., Shi, Y., & Sun, Z. (2023). Regulatory function of steroid receptor coactivators (SRCs) in cell metabolism: implications for cancer and immunity. Critical Reviews in Immunology. (Under review)
  • Zhang, W., Cao, X., Zhong, X., Wu, H., Shi, Y., Feng, M., Wang, Y., Ann, D., Gwack Y., Shang, W., & Sun, Z. (2023). SRC2 controls CD4+ T cell activation via stimulating c-Myc mediated up-regulation of amino acid transporter Slc7a5. Proceedings of the National Academy of Sciences (PNAS), 120(18), e2221352120 (Direct Submission). (IF=12.79)
  • Zhang, W., Cao, X., Zhong, X., Wu, H., Feng, M., Gwack Y., & Sun, Z. (2022). Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via upregulating Nr4a2. Science Advances, 8 (24), eabn7662. (IF= 14.957)
  • Zhang, W., Chen, J., Lu, Y. & Liu, S. (2022). Pre-treatment of coconut kernels by proteases to modulate the flavour of coconut oil. Food Bioscience, 101736. (IF= 5.318)
  • Zhang, W., Xu, C., & Liu, S. (2019). Aroma modulation of vegetable oils - a review. Critical Reviews in Food Science and Nutrition, 1-14. (IF= 11.208)
  • Zhang, W., Zhao, F., Zhao, F., Yang, T., & Liu, S. (2018). Solid-state fermentation of palm kernels by Yarrowia lipolytica modulates the aroma of palm kernel oil. Scientific Reports, 9(1), 2538. (IF= 4.996)
  • Zhang, W., Leong, S. M., Zhao, F., Zhao, F., Yang, T., & Liu, S. (2018). Viscozyme L pretreatment on palm kernels improved the aroma of palm kernel oil after kernel roasting. Food Research International, 107,172-181. (IF= 7.425)
  • Zhang, W., & Liu, S. (2018). Pretreatment of palm kernels with proteases modified volatile flavor compounds of palm kernel oil. Journal of Food Biochemistry, 2018: e12622. (IF= 3.654)
  • Zhang, W., Zhao F., Yang, T., & Liu, S. (2017). Protease/peptidase (Flavourzyme) pretreatment on palm kernels improves the aroma of resultant palm kernel oil after kernel roasting. European Journal of Lipid Science and Technology, 119, 1600460. (IF= 3.196)
  • Zhang, W., Zhao, F., Yang, T., Zhao, F., & Liu, S. (2017). Celluclast 1.5 L pretreatment enhanced aroma of palm kernels and oil after kernel roasting. Journal of the Science of Food and Agriculture, 97(15), 5146-5157. (IF= 4.125)
  • Zhang, W., Zhao, F., Zhao, F., Yang, T., & Liu, S. (2017). Pentopan mono BG pretreatment of palm kernels modified the aroma of palm kernel oil after kernel roasting. LWT-Food Science and Technology, 86, 577-585. (IF= 6.056)
  • Zhang, W., Wang, R., Yuan, Y., Yang, T., & Liu, S. (2016). Changes in volatiles of palm kernel oil before and after kernel roasting. LWT-Food Science and Technology, 73, 432-441. (IF= 6.056)
  • Zhong, X., Wu, H., Ouyang, C., Zhang, W., Shi, Y., Wang, YC., Ann, D., Gwack, Y., Shang, W., & Sun, Z. (2023). SRC-2 stimulates CD8+ T cell activation by up-regulating PGC-1α critical for mitochondrial function. Cancer Immunology Research (Accepted). (IF= 12.02)
  • Zhong, X., Wu, H., Zhang, W., Gwack, Y., Shang, W., Lee, K. O., Isakov, N., He, Z., & Sun, Z. (2022). Decoupling the role of RORγt in the differentiation and effector function of TH17 cells. Science advances, 8(42), eadc9221. (IF= 14.957)
  • Cao, X., Wang, Y., Zhang, W., Zhong, X., Gunes, GE., Dang, J., Wang, J., Epstein, AL., Querfeld, C., Sun, Z., Rosen, ST., & Feng, M. (2022). Targeting macrophages for enhancing CD47 blockade-elicited lymphoma clearance and overcoming tumor-induced immunosuppression. Blood, 139(22) (IF= 25.476)
  • Cao, X., Chen, J., Li, B., Dang, J., Zhang, W., Zhong, X., Wang, C., Raoof, M., Sun, Z., Yu, J., Fakih, MG. & Feng, M. (2022). Promoting antibody-dependent cellular phagocytosis for effective macrophage-based cancer immunotherapy. Science Advances, 8(11): eabl9171. (IF= 14.957)
  • Cao, X, Cao, L, Zhang, W., Lu, R, Bian, JS, & Nie, X. (2020). Therapeutic potential of sulfurcontaining natural products in inflammatory diseases. Pharmacology & Therapeutics, 107687 (IF= 13.4)
  • Cao, X., Zhang, W., Moore, PK., & Bian, J. Protective smell of hydrogen sulfide and polysulfide in cisplatin induced nephrotoxicity (2019). International Journal of Molecular Sciences, 20(2). (IF= 6.208)
获奖
  • 上海市海外高层次人才
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