教师名录 - 上海交通大学农业与生物学院

研究内容

从事植物次生代谢相关的研究，主要研究工作包括：
1.以青蒿、丹参作为底盘进行植物次生代谢和合成生物学的研究。
2.以青蒿为模式，探索次生代谢产物合成相关的植物多细胞腺毛发育模式。

承担项目

国家自然科学基金委员会，面上项目，32070329，AaMYB16-AaHD1-AaMYB5复合体通过调控青蒿腺毛起始发育影响青蒿素合成的分子机理研究，2021/01-2024/12，58万元，已结题，主持。
科技部，国家重点研发计划，2018YFA0900604，重要活性代谢物在植物底盘中的高效定向合成，2019/07-2024/06，594万元，已结题，参加。
美国比尔和梅琳达盖茨基金会、OPP1199872、Identification and functional characterization of putative enzymes involved in the artemisinin biosynthesis from Artemisia annua，2018/09-2020/02，75万美元，已结题，参加。
国家自然科学基金委员会，面上项目，31770327，AaMYB2介导光信号和茉莉酸信号互作调控青蒿素合成的分子机理研究，2018/01-2021/12，60万元，已结题，主持。
上海市科委，自然基金面上项目，16ZR1418000，光信号调控青蒿素合成的分子机理研究，2016/7-2019/6，20万元，已结题，主持。
中国中医科学院，中央本级重大增减支项目，2060302-2402-06，光抑制根中丹参酮合成的表观遗传分子机制解析，2024/10-2026/12，55万元，在研，主持
上海市科委，自然基金面上项目，25ZR1401180，青蒿分泌型腺毛和T形腺毛起始发育的分子机制研究，2025/7-2028/6，20万元，在研，主持
横向课题，人工智能辅助生物防晒蛋白的设计、筛选和制造，2026/05-2028/6，30万元，主持。
国家自然科学基金委员会，面上项目，32670501，AaVQ18通过与AaGSW1及AaGSW2互作共调控青蒿素代谢和青蒿腺毛起始发育的机理，2027/01-2030/12，50万元，主持。

论文

Yu Wu, Hang Liu, Mengying Sun, Yi Ye, Yaojie Zhang, Gaopeng Wang, Xiang Liu*, Han Zheng*, Ling Li*,Screening of regulatory factors for tanshinone biosynthesis in response to drought stress, Industrial Crops and Products,Volume 248,2026,123641.
Hangyu Wen#, Wei Wang#, Weizhi He, Hang Liu, Lei Su, Xinyi Hu, Xin Yan, Bowen Peng, Yaojie Zhang, Pin Liu, Shouchao Yan, Eddie Wu, Xueqing Fu, Li Ren, Kexuan Tang, Ling Li*. Comprehensive genome-wide identification and functional characterization of non-specific lipid transfer proteins in Artemisia annua L.. Medicinal Plant Biology,2026,5: e002 doi: 10.48130/mpb-0025-0040.
Chen L, Diao L, Ruan J, Deng Y, Zhang K, Guan Y, Li L, Liang M, Peng L, Shi J, Zhang S, Liu M, Li Y, Mao Z, Wang W, Yang HQ, Guo T. The COP1-ADA2b module mediates light regulation of DNA double-strand break repair in Arabidopsis. Nat Commun. 2026 Mar 13;17(1):3876. doi: 10.1038/s41467-026-70673-z.
Xinyi Hu, Hang Liu, Tiantian Chen, Yi Ye, Jin Shao, Xin Yan, Bowen Peng, Ling Li*, Kexuan Tang*,AaPDF2 promotes glandular trichome formation in Artemisia annua through jasmonic acid signaling,Industrial Crops and Products,Volume 234,2025,121630.
Yao Q, Ye Y, Liu Q, Tian Y, Xiang L, Li L, Liu H, Zhang Y, Yu M, Zheng H, Huang L. Development and application of base editing systems in Salvia miltiorrhiza for precise metabolic engineering. Plant Biotechnol J. 2025 Dec;23(12):5619-5621. doi: 10.1111/pbi.70234.
Weizhi He; Hang Liu; Zhangkuanyu Wu; Qing Miao; Xinyi Hu; Xin Yan; Hangyu Wen; Yaojie Zhang; Xueqing Fu; Li Ren; Kexuan Tang; Ling Li* ; The AaBBX21–AaHY5 module mediates light‐regulated artemisinin biosynthesis in Artemisia annua L., Journal of Integrative Plant Biology,2024, 66(8): 1735-1751.
Wei Qin; Yongpeng Li; Hang Liu; Xin Yan; Xinyi Hu; Tiantian Chen; Saeed-ur Rahman; Junfeng Cao; Han Zheng; Ling Li*; Kexuan Tang* ; Integrated multi-omics profiling reveals a landscape of dramatic metabolic defect in Artemisia annua, Horticulture Research, 2024, 11(174):1452-1454.
Hang Liu; Weizhi He; Xinghao Yao; Xin Yan; Xiuyun Wang; Bowen Peng; Yaojie Zhang; Jin Shao; Xinyi Hu; Qing Miao; Ling Li*; Kexuan Tang* ; The Light- and Jasmonic Acid-Induced AaMYB108-like Positive Regulates the Initiation of Glandular Secretory Trichome in Artemisia annua L., International Journal of Molecular Sciences, 2023, 24(16): 12929.
Weizhi He; Hang Liu; Yongpeng Li; Zhangkuanyu Wu; Yan Xie; Xin Yan; Xiuyun Wang; Qing Miao; Tiantian Chen; Saeed-ur Rahman; Xinghao Yao; Yaojie Zhang; Chen Wang; Xinyi Hu; Xueqing Fu; Li Ren; Kexuan Tang; Ling Li* ; Genome-wide characterization of B-box gene family in Artemisia annua L. and its potential role in the regulation of artemisinin biosynthesis, Industrial Crops and Products, 2023, 199: 116736.
Guo T, Liu M, Chen L, Liu Y, Li L, Li Y, Cao X, Mao Z, Wang W, Yang HQ. Photoexcited cryptochromes interact with ADA2b and SMC5 to promote the repair of DNA double-strand breaks in Arabidopsis. Nat Plants. 2023 Aug;9(8):1280-1290. doi: 10.1038/s41477-023-01461-6.
Xie L#, Yan T#, Li L#, Chen M, Hassani D, Li Y, Qin W, Liu H, Chen T, Fu X, Shen Q, Rose JKC, Tang K*. An HD-ZIP-MYB complex regulates glandular secretory trichome initiation in Artemisia annua. New Phytol. 2021 May 27. doi: 10.1111/nph.17514.
Xie L, Yan T, Li L, Chen M, Ma Y, Hao X, Fu X, Shen Q, Huang Y, Qin W, Liu H, Chen T, Hassani D, Kayani SL, Rose JKC, Tang K*. The WRKY transcription factor AaGSW2 promotes glandular trichome initiation in Artemisia annua. J Exp Bot. 2021 Feb 27;72(5):1691-1701.
Hao, X., Zhong, Y., Fu, X., Lv, Z., Shen, Q., Yan, T., Shi, P., Ma, Y., Chen, M., Lv, X., Wu, Z., Zhao, J., Sun, X., Li, L*., and Tang, K.X*. (2017). Transcriptome Analysis of Genes Associated with the Artemisinin Biosynthesis by Jasmonic Acid Treatment under the Light in Artemisia annua. Front Plant Sci 8, 971.
Hao, X., Zhong, Y., Ni Tzmann, H.W., Fu, X., Yan, T., Shen, Q., Chen, M., Ma, Y., Zhao, J., Osbourn, A., Li, L*., and Tang, K.X*. (2019). Light-Induced Artemisinin Biosynthesis Is Regulated by the bZIP Transcription Factor AaHY5 in Artemisia annua. Plant & cell physiology 60, 1747-1760.
Li, L., Hao, X., Liu, H., Wang, W., Fu, X., Ma, Y., Shen, Q., Chen, M., and Tang, K.X*. (2019). Jasmonic acid-responsive AabHLH1 positively regulates artemisinin biosynthesis in Artemisia annua. Biotechnology and applied biochemistry 66, 369-375.
Wang, W., Lu, X., Li, L., Lian, H., Mao, Z., Xu, P., Guo, T., Xu, F., Du, S., Cao, X., Wang, S., Shen, H., and Yang, H.Q*. (2018). Photoexcited CRYPTOCHROME1 Interacts with Dephosphorylated BES1 to Regulate Brassinosteroid Signaling and Photomorphogenesis in Arabidopsis. Plant Cell 30, 1989-2005.
Shi, P., Fu, X., Shen, Q., Liu, M., Pan, Q., Tang, Y., Jiang, W., Lv, Z., Yan, T., Ma, Y., Chen, M., Hao, X., Liu, P., Li, L., Sun, X., and Tang, K.X*. (2018). The roles of AaMIXTA1 in regulating the initiation of glandular trichomes and cuticle biosynthesis in Artemisia annua. The New phytologist 217, 261-276.
Yan, T#., Li, L#., Xie, L., Chen, M., Shen, Q., Pan, Q., Fu, X., Shi, P., Tang, Y., Huang, H., Huang, Y., Huang, Y., and Tang, K.X*. (2018). A novel HD-ZIP IV/MIXTA complex promotes glandular trichome initiation and cuticle development in Artemisia annua. The New phytologist 218, 567-578.
Shen, Q., Zhang, L., Liao, Z., Wang, S., Yan, T., Shi, P., Liu, M., Fu, X., Pan, Q., Wang, Y., Lv, Z., Lu, X., Zhang, F., Jiang, W., Ma, Y., Chen, M., Hao, X., Li, L., Tang, Y., Lv, G., Zhou, Y., Sun, X., Brodelius, P.E., Rose, J.K.C., and Tang, K.X*. (2018). The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis. Mol Plant 11, 776-788.
Yan, T., Chen, M., Shen, Q., Li, L., Fu, X., Pan, Q., Tang, Y., Shi, P., Lv, Z., Jiang, W., Ma, Y.N., Hao, X., Sun, X., and Tang, K.X*. (2017). HOMEODOMAIN PROTEIN 1 is required for jasmonate-mediated glandular trichome initiation in Artemisia annua. The New phytologist 213, 1145-1155.
Ma, Y.N., Xu, D.B., Li, L., Zhang, F., Fu, X.Q., Shen, Q., Lyu, X.Y., Wu, Z.K., Pan, Q.F., Shi, P., Hao, X.L., Yan, T.X., Chen, M.H., Liu, P., He, Q., Xie, L.H., Zhong, Y.J., Tang, Y.L., Zhao, J.Y., Zhang, L.D., Sun, X.F., and Tang, K.X*. (2018). Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in Artemisia annua. Sci Adv 4, eaas9357.
Zhang, F#., Liu, S#., Li, L#., Zuo, K., Zhao, L., and Zhang, L*. (2016). Genome-Wide Inference of Protein-Protein Interaction Networks Identifies Crosstalk in Abscisic Acid Signaling. Plant Physiol 171, 1511-1522.
Li, L., Shi, Z.Y., Li, L., Shen, G.Z., Wang, X.Q., An, L.S., and Zhang, J.L*. (2010). Overexpression of ACL1 (abaxially curled leaf 1) increased Bulliform cells and induced Abaxial curling of leaf blades in rice. Mol Plant 3, 807-817.

专利著作

黎凌; 贺威智; 王伟; 刘航; 唐克轩; 付雪晴; 孙小芬; 赵静雅; 一种利用脂质转运蛋白基因启动子调控目的基因表达的方法、转化载体及其应用, 2026-06-02, 中国, ZL 202211397159.2

获奖

自然科学奖