PI
吴紫云 长聘教轨副教授
农生学院农科创新大楼B211 wuziyun@sjtu.edu.cn 021-34208217
研究领域:食品营养与生物衰老
2014年毕业于新加坡国立大学,获食品科学与工程博士学位,2014年至2019年于哈佛大学医学院从事博士后研究。2019年至今,上海交通大学长聘教轨副教授。长期专注于食品营养与生物衰老研究,成果显著。在Cell Metabolism, Nature Communications, EMBO Reports, BMC Biology, Journal of Agricultural and Food Chemistry等国际著名期刊共发表论文23篇,受到本领域知名专家学者的高度评价,多次应邀参加国际顶级学术会议。曾获国际食品科技联盟(IUFoST)青年科学家奖“Young Scientist Award”、上海浦江人才计划、上海市海外高层次人才、国家级青年人才等荣誉。目前主持基金包括国家自然科学基金面上和优秀青年科学基金项目、上海市浦江人才项目等。 主要研究领域 《食品营养与生物衰老》课题组主要围绕食品营养影响衰老发生与发展的基础科学问题,用酵母、线虫和小鼠等模式生物,结合分子遗传学、生物化学、代谢组和转录组学等技术手段,重点分析饮食影响先天免疫的共性机制,探究食品营养影响长寿的秘诀,解析先天免疫调控衰老的保守机制,以期揭示营养调控衰老的分子机制,为明确回答“吃什么样的食物可能有利于改善慢性炎症和延长寿命?”这一朴实问题提供科学基础,为长寿膳食配方的开发提供理论基础。 人员招聘(长期有效) 欢迎海内外对食品营养与生物衰老抱有浓厚兴趣的本科生(PRP等项目)、研究生(每年1名博士2名硕士)、博士后及青年学者(助理研究员)加盟。应聘者将个人简历等相关资料发送至wuziyun@sjtu.edu.cn。通过初审者,将尽快安排面试。
论文
  • Campos JC#, Wu Z#, Rudich PD, et al. Mild mitochondrial impairment enhances innate immunity and longevity through ATFS-1 and p38 signaling. EMBO reports, 2021, e52964.
  • Wu Z, Isik M, Moroz N, et al. Dietary restriction extends lifespan through metabolic regulation of innate immunity. Cell Metabolism, 2019, 29(5), 1192-1205.Research Highlight by Nature Reviews Endocrinology, 2019, 15(6), 317.Spotlight by Molecular Cell, 2019, 74(5), 864-865.F1000 recommendations: Pankaj Kapahi, “Very Good”F1000 recommendations: Dongsheng Cai, “Exceptional”F1000 recommendations: Thomas Flatt, “Very Good”F1000 recommendations: Siegfried Hekimi, “Exceptional”
  • Wu Z#, Senchuk MM#, Dues DJ, et al. Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways. BMC Biology, 2018, 16, 147.
  • Wu Z, Song L, Liu S and Huang D. Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae. Applied microbiology and biotechnology, 2014, 98(20), 8617-8628.
  • Wu Z, Liu S, and Huang D. Independent and additive effects of glutamic acid and methionine on yeast longevity. Plos One, 2013, 8(11): e79319.
  • Wu Z, Song L, Feng S, et al. Germination dramatically increases isoflavonoid content and diversity in chickpea (Cicer arietinum L.) seeds. Journal of Agricultural and Food Chemistry. 2012, 60, 8606−8615.
  • Wu Z, Song L, Liu S and Huang D. A high throughput screening assay for determination of chronological lifespan of yeast. Experimental Gerontology. 2011, 46, 915-922.
  • Wu Z, Song L and Huang D. Food grade fungal stress on germinating peanut seeds induced phytoalexins and enhanced polyphenolic antioxidants. Journal of Agricultural and Food Chemistry. 2011, 59, 5993−6003.
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