研究内容
- 1、食品分子营养，主要包括天然产物抗氧化应激、调节脂代谢等分子机理研究。
- 2、食品毒理学，主要包括食品加工过程中毒性物质产生机理及毒性机理。
承担项目
- 国家自然科学基金面上项目：《原花青素B2通过XBP1-s干预高脂环境诱导RPE细胞氧化应激机制研究》， 31271843，2016/01-2019/12，主持。
- 国家自然科学基金面上项目，31271843、《基于UPR分子伴侣途径的葡萄多酚类物质延缓RPE衰老保护视觉功能的机制研究》、2013/01-2016/12，主持。
- 国家863项目子课题：《活性蛋白（肽）生物活性集成、体系化评价技术研究》 ，2013AA102200，2013/01-2017/12，主持。
- 上海市科委项目标准化专项，07DZ05019、《分子印迹固相萃取连用HPLC快速检植物性食品中农残抗蚜威及转基因玉米品系特异性检测技术标准研究》、2007/01-2009/12，主持。
- 上海市科委项目标准化专项，06DZ05036、《食用植物性产品快速检测技术研究》子课题《软饮料中苯成分测量方法》、2006/01-2008/12，主持。
论文
- Bing Lu, Tao Sun,Weinan Li, Xiaodong Su, Xiaomin Yao, Xiangjun Sun(*). Piceatannol protects ARPE-19 cells against vitamin A dimer-mediated photo-oxidative damage through activation of Nrf2/NQO1 signalling. J Func Foods, 2016, 26: 739–749.
- Man Liu，Guoren Huang，Thomas T.Y. Wang，Xiangjun Sun(*) , Liangli (Lucy) Yu(*), 3-MCPD 1-palmitate induced tubular cell apoptosis in vivo via JNK/p53 pathways，Toxico Sci, 2016, 151: 181-192.
- Jie Liu, Yanfang Li, Haiming Shi, Thomas Wang, Xianli Wu, Xiangjun Sun(*), Liangli (Lucy) Yu(*), Components characterization of total tetraploid jiaogulan (Gynostemma pentaphylla) saponin and its cholesterol-lowering properties, J Func Foods, 2016, 23: 542-555.
- Weinan Li, Yun Jiang, Tao Sun, Xiaomin Yao, Xiangjun Sun(*), Supplementation of procyanidins B2 attenuates photooxidation-induced apoptosis in ARPE-19 cells, Int J Food Sci Nutr, 2016, 67 (6): 650–659.
- Man Liu, Jie Liu, Yizhen Wu, Boyan Gao, Pingping Wu, Haiming Shi, Xiangjun Sun(*), Haiqiu Huang, Thomas T. Y. Wang, Liangli (Lucy) Yu(*), Preparation of five 3-MCPD fatty acid esters,and the effects of their chemical structures on acute oral toxicity in Swiss mice, J Sci Food Agric, 2016, (wileyonlinelibrary.com) DOI 10.1002/jsfa.7805.
- Jie Liu, Puyu Yang, Haiming Shi, Xiangjun Sun(*), Seong-Ho Lee and Liangli (Lucy)Yu(*), A novel Gynostemma pentaphyllum saponin and its adipogenesis inhibitory effect through modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion, J Func Foods, 2015,17:552-562.
- Zhao Zhao, Tao Sun, Yun Jiang , Lijiang Wu, Xiangzhong Cai, Xiaodong Sun(*), Xiangjun Sun(*) , Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols, Food Chem Toxicol, 2014,74 : 216–224.
- Jingyang Feng , Xunjie Chen , Xiangjun Sun, Fenghua Wang, Xiangjun Sun. Expression of endoplasmic reticulum stress markers GRP78 and CHOP induced by oxidative stress in blue light-mediated damage of A2E-containing retinal pigment epithelium cells. Ophthalmic Res, 2014, 52 (4) : 224-233.
- Lei Zhang, Fenghua Wang, Yuan Jiang, Shan Xu, Fengqing Lu, Wenqiu Wang, Xiangjun Sun, Xiaodong Sun, Migration of retinal pigment epithelial cells is EGFR/PI3K/AKT dependent, Front Biosci (schol Ed), 2013, 5: 661-671
- Tao Sun, Qiuyu Chen, Lijiang Wu, Xiaomin Yao, Xiangjun Sun(*), Antitumor and antimetastatic activities of grape skin polyphenols in a murine model of breast cancer, Food Chem Toxicol, 2012, 50 (10) : 3462-3467.
- Ying Liu, Ming Wu, Wuzhou Wan , Jingna Wang, Ronghua Sun, Yang De, Xiangjun Sun, Dalong Ma , Guoguang Ying ,Ning Zhang, Down-Regulation of 3-Phosphoinositide-Dependent Protein Kinase-1 Levels Inhibits Migration and Experimental Metastasis of Human Breast Cancer Cells, Molecular Cancer research, 2009, 7(6): 944-954.
- Jingna Wang, Wuzhou Wan, Ronghua Sun, Ying Liu, Xiangjun Sun, Dalong Ma, Ning Zhang, Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells, Cellular Signalling 2008; 20 (6):1025–1034.
- Xiangjun Sun, Dongning Wang , Weijie Zhang, Xiangfu Wu, Expression of an antimicrobial peptide identified in the male reproductive system of rats , Molecular Biotecnology 2004; 28(3):185-190.
- 孙向军，王东宁，张惟杰，吴祥甫, 东方鲎Factor C中的结构域在结合脂多糖中的作用, 《生物化学与生物物理进展》,2004,31(8):736-740