PI组长：
       朱勃  长聘教轨/副教授

研究方向：
       植物-细菌互作表观遗传学

主要研究领域：

1. 转录后修饰（表观转录组学）在病原细菌与宿主互作过程中的作用

2. 互作过程中，病原细菌非编码RNA（sRNA）与宿主非编码RNA（LncRNA及circRNA）所起的作用

3. 基因水平转移（HGT）对于病原细菌致病性及微环境适应性所起的作用

PI研究组代表性成果：

1、主要研究项目：

国家重点研发计划，2018YFD0201200，露地蔬菜化肥农药减施技术集成研究与示范，子课题参加

国家重点研发计划项目，2017YFD0201100，新型高效生物杀菌剂研发，子课题参加

国家自然科学基金青年科学基金项目“阴沟肠杆菌复合菌群的系统分类及其在浙江省主要饮用水源地的多样性分布与风险评估”，项目批准号:31200003，主持

2、成果专利与奖励：

朱勃, 谢关林等. 发明专利: 用于诊断桑细菌性枯萎病的引物及诊断方法. 专利号：CN200910157005.4

3、代表论著：

1. Zhang, Y., Chen, P., Ye, G., Lin, H., Ren, D., Guo, L., Zhu, B. and Wang, Z. (2018) Complete Genome Sequence of Pseudomonas Parafulva PRS09-11288, a Biocontrol Strain Produces the Antibiotic Phenazine-1-carboxylic Acid. Curr. Microbiol., 1-5. (co-corresponding author)

2. Song, W., Wang, S., Shen, J. and Zhu, B. (2018) Complete Genome Sequence of Massilia oculi sp. nov. CCUG 43427 T (= DSM 26321 T), the Type Strain of M. oculi, and Comparison with Genome Sequences of Other Massilia Strains. Curr. Microbiol., 1-5. (co-corresponding author)

3. Nazir, F., Ibrahim, M., Zaman, G., Hussain, A., Yar, A.M. and Bo, Z. (2018) Genetic Diversity and Functional Analysis of Sigma Factors in Enterobacter cloacae Complex Resourced From Various Niche. Evol. Bioinfo., 14, 1176934318754878. (co-corresponding author)

4. Zhu B, Wang S, Li O, Hussain A, Hussain A, Shen J, Ibrahim M 2017. High-quality genome sequence of human pathogen Enterobacter asburiae type strain 1497-78 T. J Glob Antimicrob Re 8:104-105. (first author)

5. Zhu B, Muhammad Ibrahim, et al. 2016. Multi-omics analysis of niche specificity provides new insights into ecological adaptation in bacteria. ISMEJ.10:2072-2075. (IF=9.3, first author)

6.Cui, Z., Ojaghian, M. R., Tao, Z., Kakar, K. U., Zeng, J., Zhao, W., Duan, Y., Vera Cruz, C. M., Li, B., Zhu, B., and Xie, G. 2016. Multiplex PCR assay for simultaneous detection of six major bacterial pathogens of rice. J Appl Microbiol 120:1357-1367. (co-corresponding author)

7. Liu H, Ibrahim M, Qiu H, Kausar S, Ilyas M, Cui Z, Hussain A, Li B, Waheed A & Zhu B (2015) Protein Profiling Analyses of the Outer Membrane of Burkholderia cenocepacia Reveal a Niche-Specific Proteome. Microb Ecol 69: 75-83. (co-corresponding author, IF=3.2)

8. Gemayel, R., Chavali, S., Pougach, K., Legendre, M., Zhu, B., Boeynaems, S., van der Zande, E., Gevaert, K., Rousseau, F., and Schymkowitz, J (2015) Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity. Mol. Cell 59:615-627.

9. Pougach, K., Voet, A., Kondrashov, F. A., Voordeckers, K., Christiaens, J. F., Baying, B., Benes, V., Sakai, R., Aerts, J., Zhu, B., Patrick, V. D., and Kevin, J. V (2014) Duplication of a promiscuous transcription factor drives the emergence of a new regulatory network. Nature communications 5.

10.New AM, Cerulus B, Govers SK, Perez-Samper G, Zhu B, Boogmans S, Xavier JB & Verstrepen KJ (2014) Different levels of catabolite repression optimize growth in stable and variable environments. PLoS Biol 12: e1001764.

11. Liu H, Yang C-L, Ge M-Y, Ibrahim M, Li B, Zhao W-J, Chen G-Y, Zhu B & Xie G-L (2014) Regulatory role of tetR gene in a novel gene cluster of Acidovorax avenae subsp. avenae RS-1 under oxidative stress. Front Microbiol 5. (co-corresponding author, IF=4.0)

12. Crauwels S, Zhu B, Steensels J, Busschaert P, De Samblanx G, Marchal K, Willems KA, Verstrepen KJ & Lievens B (2014) Assessing genetic diversity in Brettanomyces yeasts using DNA fingerprinting and whole genome sequencing. Appl Environ Microbiol AEM. 00601-00614.

13. Chen M, Zhu B, Lin L, Yang L, Li Y & An Q (2014) Complete genome sequence of Kosakonia sacchari type strain SP1T. Stand Genomic Sci 9.

14. Zhu B, Zhou Q, Lin L, Hu C, Shen P, Yang L, An Q, Xie G & Li Y (2013) Enterobacter sacchari sp. nov., a nitrogen-fixing bacterium associated with sugar cane (Saccharum officinarum L.). Int J Syst Evol Microbiol 63: 2577-2582. (First Author)

15.Aslankoohi E, Zhu B, Rezaei MN, Voordeckers K, De Maeyer D, Marchal K, Dornez E, Courtin CM & Verstrepen KJ (2013) Dynamics of the Saccharomyces cerevisiae transcriptome during bread dough fermentation. Appl Environ Microbiol 79: 7325-7333.

16. Zhu B, Zhou Q, Xie G, Zhang G, Zhang X, Wang Y, Sun G, Li B & Jin G (2012) Interkingdom Gene Transfer May contribute to the evolution of phytopathogenicity in Botrytis Cinerea. Evol Bioinform 8: 105. (First Author)

17. Zhu B, Ye S, Chang S, Chen M, Sun L & An Q (2012) Genome sequence of the pathogenic Herbaspirillum seropedicae strain Os45, isolated from rice roots. J Bacteriol 194: 6995-6996. (First Author, IF=3.2)

18. Zhu B, Liu H, Tian W-X, Fan X-Y, Li B, Zhou X-P, Jin G-L & Xie G-L (2012) Genome sequence of Stenotrophomonas maltophilia RR-10, isolated as an endophyte from rice root. J Bacteriol 194: 1280-1281. (First Author, IF=3.2)

19. Zhu B, Chen M, Lin L, Yang L, Li Y & An Q (2012) Genome Sequence of Enterobacter sp. Strain SP1, an Endophytic Nitrogen-Fixing Bacterium Isolated from Sugarcane. J Bacteriol 194: 6963-6964. (First Author, IF=3.2)

20. Liu H, Tian W-X, Ibrahim M, Li B, Zhang G-Q, Zhu B & Xie G-L (2012) Characterization of pilP, a gene required for twitching motility, pathogenicity, and biofilm formation of Acidovorax avenae subsp. avenae RS-1. Eur J Plant Pathol 134: 551-560. (co-corresponding author)

21. Zhu B, Zhou S, Lou M, Zhu J, Li B, Xie G, Jin G & De Mot R (2011) Characterization and inference of gene gain/loss along Burkholderia evolutionary history. Evol Bioinform 7: 191. (First Author)

22. Zhu B, Zhang G-Q, Lou M-M, Tian W-X, Li B, Zhou X-P, Wang G-F, Liu H, Xie G-L & Jin G-L (2011) Genome sequence of the Enterobacter mori type strain, LMG 25706, a pathogenic bacterium of Morus alba L. J Bacteriol 193: 3670-3671. (First Author, IF=3.2)

23. Zhu B, Lou M-M, Xie G-L, Zhang G-Q, Zhou X-P, Li B & Jin G-L (2011) Horizontal gene transfer in silkworm, Bombyx mori. BMC Genomics 12: 248. (First Author, IF=4.2)

24. Zhu B, Lou M-M, Xie G-L, Wang G-F, Zhou Q, Wang F, Fang Y, Su T, Li B & Duan Y-P (2011) Enterobacter mori sp. nov., associated with bacterial wilt on Morus alba L. Int J Syst Evol Microbiol 61: 2769-2774. (First Author)

25. Lou M, Jin G, Tian W, Zhang G, Fan X, Wang F, Zhu B & Xie G (2011) Specific and Sensitive Detection of Enterobacter mori Using Reliable RT-PCR. Plant Dis 95: 1070-1074. (co-corresponding author)

26. Zhu B, Wang G, Xie G, Zhou Q, Zhao M, Praphat K, Li B & Tian W (2010) Enterobacter spp.: a new evidence causing bacterial wilt on mulberry. Sci China C Life Sci 53: 292-300. (First Author)