Research interests

1. Emerging and Zoonotic Diseases
2. Virome
3. Molecular mechanism of host-shift of avian influenza viruses and coronaviruses

Employment

• 2010-2012 Associate researcher, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
• 2013-2015 Researcher, Joint Influenza Research Centre, Shantou University Medical College, Shantou, China
• 2016-2024 Professor, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
• 2025-Present Professor, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

Education

• 2004 BSc, Biology, University of Science and Technology of China
• 2010 Ph.D., Genetics, University of Chinese Academy of Sciences

Publications (*co-first author)

1. Meng, Y., Irwin, D.M., and Shen, Y*., Ecology of SARS-CoV-2 in the post-pandemic era. Lancet Microbe, 2023. 4(4): p. e208.

2. Liang, X., Zhang, Z., Wang, H., Lu, X., Li, W., Lu, H., Roy, A., Shen, X., Irwin, D.M., and Shen, Y*., Early-life prophylactic antibiotic treatment disturbs the stability of the gut microbiota and increases susceptibility to H9N2 AIV in chicks. Microbiome, 2023. 11(1): p. 163.

3. Liang, X., Chen, X., Zhai, J., Li, X., Zhang, X., Zhang, Z., Zhang, P., Wang, X., Cui, X., Wang, H., Zhou, N., Chen, Z.J., Su, R., Zhou, F., Holmes, E.C., Irwin, D.M., Chen, R.A., He, Q., Wu, Y.J., Wang, C., Du, X.Q., Peng, S.M., Xie, W.J., Shan, F., Li, W.P., Dai, J.W., Shen, X., Feng, Y., Xiao, L., Chen, W*., and Shen, Y*., Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins. PLoS Pathog, 2023. 19(5): p. e1011384.

4. Huang, X.Y., Chen, Q., Sun, M.X., Zhou, H.Y., Ye, Q., Chen, W., Peng, J.Y., Qi, Y.N., Zhai, J.Q., Tian, Y., Liu, Z.X., Huang, Y.J., Deng, Y.Q., Li, X.F., Wu, A., Yang, X., Yang, G*., Shen, Y*., and Qin, C.F*., A pangolin-origin SARS-CoV-2-related coronavirus: infectivity, pathogenicity, and cross-protection by preexisting immunity. Cell Discov, 2023. 9(1): p. 59.

5. Cui, X., Fan, K., Liang, X., Gong, W., Chen, W., He, B., Chen, X., Wang, H., Wang, X., Zhang, P., Lu, X., Chen, R., Lin, K., Liu, J., Zhai, J., Liu, D.X., Shan, F., Li, Y., Chen, R.A., Meng, H., Li, X., Mi, S., Jiang, J., Zhou, N., Chen, Z., Zou, J.J., Ge, D., Yang, Q., He, K., Chen, T., Wu, Y.J., Lu, H., Irwin, D.M., Shen, X., Hu, Y., Lu, X., Ding, C*., Guan, Y*., Tu, C*., and Shen, Y*., Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals. Nat Commun, 2023. 14(1): p. 2488.

6. Xiao, K., Zhai, J., Feng, Y., Zhou, N., Zhang, X., Zou, J.J., Li, N., Guo, Y., Li, X., Shen, X., Zhang, Z., Shu, F., Huang, W., Li, Y., Zhang, Z., Chen, R.A., Wu, Y.J., Peng, S.M., Huang, M., Xie, W.J., Cai, Q.H., Hou, F.H., Chen, W*., Xiao, L*., and Shen, Y*., Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins. Nature, 2020. 583(7815): p. 286-289.

7. Zhang, X., Luo, T., and Shen, Y*., Deciphering the Sharp Decrease in H7N9 Human Infections. Trends Microbiol, 2018. 26(12): p. 971-973.

8. Xiang, D., Shen, X., Pu, Z., Irwin, D.M., Liao, M., and Shen, Y*., Convergent Evolution of Human-Isolated H7N9 Avian Influenza A Viruses. J Infect Dis, 2018. 217(11): p. 1699-1707.

9. Sabir, J.S^#., Lam, T.T^#., Ahmed, M.M^#., Li, L^#., Shen, Y., Abo-Aba, S.E., Qureshi, M.I., Abu-Zeid, M., Zhang, Y., Khiyami, M.A., Alharbi, N.S., Hajrah, N.H., Sabir, M.J., Mutwakil, M.H., Kabli, S.A., Alsulaimany, F.A., Obaid, A.Y., Zhou, B., Smith, D.K., Holmes, E.C., Zhu, H., and Guan, Y., Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia. Science, 2016. 351(6268): p. 81-4.

10. Lam, T.T^#., Zhou, B^#., Wang, J^#., Chai, Y^#., Shen, Y^#., Chen, X^#., Ma, C., Hong, W., Chen, Y., Zhang, Y., Duan, L., Chen, P., Jiang, J., Zhang, Y., Li, L., Poon, L.L., Webby, R.J., Smith, D.K., Leung, G.M., Peiris, J.S., Holmes, E.C., Guan, Y., and Zhu, H., Dissemination, divergence and establishment of H7N9 influenza viruses in China. Nature, 2015. 522(7554): p. 102-5.

11. Lam, T.T^#., Wang, J^#., Shen, Y^#., Zhou, B., Duan, L., Cheung, C.L., Ma, C., Lycett, S.J., Leung, C.Y., Chen, X., Li, L., Hong, W., Chai, Y., Zhou, L., Liang, H., Ou, Z., Liu, Y., Farooqui, A., Kelvin, D.J., Poon, L.L., Smith, D.K., Pybus, O.G., Leung, G.M., Shu, Y., Webster, R.G., Webby, R.J., Peiris, J.S., Rambaut, A., Zhu, H., and Guan, Y., The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature, 2013. 502(7470): p. 241-4.