Wencan Zhang, Ph.D   Tenure-track Associate Professor Department of Animal Science Phone：+86-13482610919 Email： wenczhang@sjtu.edu.cn Address：Room A3-405, School of Agriculture and Biology, 800 Dongchuan Road, Shanghai Jiao Tong University, Shanghai, China, 200240

 

 

>>Education

• 2015- 2019      Ph.D. Faculty of Science, National University of Singapore, Singapore

 

 

>>Professional experience

2023- now       School of Agriculture and Biology, Shanghai Jiao Tong University, China

                        Tenure-track Associate Professor

2019- 2023      Department of Immunology & Theranostics,

                        Arthur Riggs Diabetes & Metabolism Research Institute,

                        City of Hope National Medical Center, USA

                        Postdoctoral Fellow

2010- 2014      Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd., China

 

 

>>Research Interests

1. Adaptive immunity in anti-infection.

2. T-cell differentiation and mediated immune response.

3. Metabolic regulation in autoimmunity.

 

 

>>Grant

Grantee. NCOA2 coactivates HIF-1α to induce Th17 cell differentiation and autoimmune responses through promoting glycolysis: the mechanistic study, funded by National natural foundation of China (NO. 82471776), 2025.01-2028.12, ¥490,000.

 

 

>>Selected Publications

  1. Zhang, W.*, Cao, X. (2025). Unfolded protein responses in T cell immunity. Fronters in Immunology, 15:1515715.

2. Wang, L.#, Hu, Z.#, Zhang, W.#, Wang, Z., Cao, M., Cao, X.（2025）. Promoting macrophage phagocytosis of cancer cells for effective cancer immunotherapy. Biochemical Pharmacology, 232:116712（# co-first）

3. Shi, Y., Zhang, W., Jia, Q., Zhong, X., Lyer, P., Wu, H., Yuan, YC., Zhao, Y., Zhang, L., Wang, L., Jia, Z., Kuo, YH., Sun, Z. (2024) Cancer-associated SF3B1-K700E mutation controls immune responses by regulating Treg function via aberrant Anapc13 splicing. Science Advances, 10(38), eado4274

4. Zhang, W., Cao, X., Zhong, X., Wu, H., Shi, Y., & Sun, Z. (2024). Regulatory function of steroid receptor coactivators (SRCs) in cell metabolism: implications for cancer and immunity. Critical Reviews in Immunology.

5. Zhang, W., Cao, X., Zhong, X., Wu, H., Shi, Y., Feng, M., Wang, Y., Ann, D., Gwack Y., Shang, W., & Sun, Z. (2023). SRC2 controls CD4⁺ T cell activation via stimulating c-Myc mediated up-regulation of amino acid transporter Slc7a5. Proceedings of the National Academy of Sciences (PNAS), 120(18), e2221352120.

6. Zhang, W., Cao, X., Zhong, X., Wu, H., Feng, M., Gwack Y., & Sun, Z. (2022). Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via upregulating Nr4a2. Science Advances, 8 (24), eabn7662.

7. Zhang, W., Chen, J., Lu, Y. & Liu, S. (2022). Pre-treatment of coconut kernels by proteases to modulate the flavour of coconut oil. Food Bioscience, 101736.

8. Zhang, W., Xu, C., & Liu, S. (2019). Aroma modulation of vegetable oils - a review. Critical Reviews in Food Science and Nutrition, 1-14.

9. Zhang, W., Zhao, F., Zhao, F., Yang, T., & Liu, S. (2018). Solid-state fermentation of palm kernels by Yarrowia lipolytica modulates the aroma of palm kernel oil. Scientific Reports, 9(1), 2538.

10. Zhang, W., Leong, S. M., Zhao, F., Zhao, F., Yang, T., & Liu, S. (2018). Viscozyme L pretreatment on palm kernels improved the aroma of palm kernel oil after kernel roasting. Food Research International, 107,172-181.

11. Zhang, W., & Liu, S. (2018). Pretreatment of palm kernels with proteases modified volatile flavor compounds of palm kernel oil. Journal of Food Biochemistry, 2018: e12622.

12. Zhang, W., Zhao F., Yang, T., & Liu, S. (2017). Protease/peptidase (Flavourzyme) pretreatment on palm kernels improves the aroma of resultant palm kernel oil after kernel roasting. European Journal of Lipid Science and Technology, 119, 1600460.

13. Zhang, W., Zhao, F., Yang, T., Zhao, F., & Liu, S. (2017). Celluclast 1.5 L pretreatment enhanced aroma of palm kernels and oil after kernel roasting. Journal of the Science of Food and Agriculture, 97(15), 5146-5157.

14. Zhang, W., Zhao, F., Zhao, F., Yang, T., & Liu, S. (2017). Pentopan mono BG pretreatment of palm kernels modified the aroma of palm kernel oil after kernel roasting. LWT-Food Science and Technology, 86, 577-585.

15. Zhang, W., Wang, R., Yuan, Y., Yang, T., & Liu, S. (2016). Changes in volatiles of palm kernel oil before and after kernel roasting. LWT-Food Science and Technology, 73, 432-441.

16. Zhong, X., Wu, H., Ouyang, C., Zhang, W., Shi, Y., Wang, YC., Ann, D., Gwack, Y., Shang, W., & Sun, Z. (2023). SRC-2 stimulates CD8+ T cell activation by up-regulating PGC-1α critical for mitochondrial function. Cancer Immunology Research (Accepted). 

17. Zhong, X., Wu, H., Zhang, W., Gwack, Y., Shang, W., Lee, K. O., Isakov, N., He, Z., & Sun, Z. (2022). Decoupling the role of RORγt in the differentiation and effector function of TH17 cells. Science advances, 8(42), eadc9221.

18. Cao, X., Wang, Y., Zhang, W., Zhong, X., Gunes, GE., Dang, J., Wang, J., Epstein, AL., Querfeld, C., Sun, Z., Rosen, ST., & Feng, M. (2022). Targeting macrophages for enhancing CD47 blockade-elicited lymphoma clearance and overcoming tumor-induced immunosuppression. Blood, 139(22)

19. Cao, X., Chen, J., Li, B., Dang, J., Zhang, W., Zhong, X., Wang, C., Raoof, M., Sun, Z., Yu, J., Fakih, MG. & Feng, M. (2022). Promoting antibody-dependent cellular phagocytosis for effective macrophage-based cancer immunotherapy. Science Advances, 8(11): eabl9171.

20. Cao, X, Cao, L, Zhang, W., Lu, R, Bian, JS, & Nie, X. (2020). Therapeutic potential of sulfurcontaining natural products in inflammatory diseases. Pharmacology & Therapeutics, 107687.

21. Cao, X., Zhang, W., Moore, PK., & Bian, J. Protective smell of hydrogen sulfide and polysulfide in cisplatin induced nephrotoxicity (2019). International Journal of Molecular Sciences, 20(2).            

 

 

>>Awards

  2023       Shanghai Overseas High-level Talents Program

2023       Presentation Award at Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center

2022       Presentation Award at Immunology & Theranostics Department, City of Hope National Medical Center