Associate Professor

Department of Food Science & Technology


Office/Lab AddressRoom B227/B214A, Building of Agriculture

Science Innovation, Dongchuan Road 800, Minhang District,

200240, Shanghai, China




>> Research Interests:

  1. Engineering and evolution of food enzyme/microbial consortium
  2. Functional and target upcycling of agri-food biomass
  3. Developing and application of synthetic biology tools


>> Education and Employment:

2021 – present, Shanghai Jiao Tong University, Tenure Track Associate Professor, PI

2018 – 2021, Singapore-MIT Alliance for Research and Technology, Postdoctoral Associate

2015 – 2018, National University of Singapore, Research fellow

2010 – 2015, East China University of Science and Technology, Ph.D. in Biochemical Engineering,

2006 – 2010, Shanxi Agricultural University, Bachelor of Science in Biological Science


>>Selected Publications:

  1. Ma, X., Liang, H., Pan, Q., Prather, K. L., Sinskey, A. J., Stephanopoulos, G., & Zhou, K. (2022). Optimization of the isopentenol utilization pathway for isoprenoid synthesis in Escherichia coli. Journal of Agricultural and Food Chemistry, 70(11), 3512-3520.
  2. Ma, X., H. Liang., S. Panda., V. Fung., J. Zhou and K. Zhou* (2022). C2 feedstock-based biomanufacturing of value-added chemicals. Current Opinion in Biotechnology 73:240-245.
  3. Wu, S, X. Ma (Co-first author)., A. Zhou., A. Valenzuela., K. Zhou*. and Y. Li* (2021). Establishment of strigolactone-producing bacterium-yeast consortium. Science Advances 7(38):1-13.
  4. Ma, X., Gözaydın. G., Yang. H., W. Ning., Han. Xi., Poon. NY., Liang. H., Yan. N* and K. Zhou* (2020). Upcycling chitin-containing waste into organonitrogen chemicals via an integrated process. Proceedings of the National Academy of Sciences 117(14).
  5. Ma, X., H. Liang., X. Cui., Y. Liu., H. Lu., W. Ning and K. Zhou* (2019). A standard for near-scarless plasmid construction using reusable DNA parts.  Nature Communications 10, 3294.
  6. Ma, X., H. Liang, K. Zhou. (2019). Constructing plasmid under GT DNA assembly standard. Protocol Exchange,
  7. Ma, X., H. Liang., C. Ning., S. Deng and E. Su* (2017).  Integrating a light-driven coenzyme regeneration system by expression of an alcohol dehydrogenase in phototrophic bacterium for synthesis of chiral alcohol. Journal of Biotechnology 259: 120-125.
  8. Ma, X., Y. Zhu., M. Sun., S. Yang., E. Su* and D. Wei* (2016). High-level expression of Cephalosporin C deacetylase from Bacillus subtilis SIL 3 in Escherichia coli by a multilevel collaborative strategy. Biochemical Engineering Journal 114: 183-190.
  9. Deng, S., X. Ma (Co-first author)., M. Sun., D. Wei* and E. Su* (2016). Efficient enzymatic synthesis of ampicillin using mutant Penicillin G acylase with bio-based solvent glycerol. Catalysis Communications 79: 31-34.
  10. Deng, S., X. Ma (Co-first author)., E. Su* and D. Wei* (2016). Efficient cascade synthesis of ampicillin from penicillin G potassium salt using wild and mutant penicillin G acylase from Alcaligenes faecalis. Journal of biotechnology 219: 142-148.
  11. Ma, X., E. Su., S. Deng* and D. Wei* (2015). An effective method for extraction of glutaryl-7-aminocephalosporanic acid acylase from recombinant E. coli cells. Biotechnology and Bioprocess Engineering 20(4): 718-724.
  12. Zhu, S., X. Ma (Co-first author)., E. Su* and D. Wei* (2015). Efficient hydration of 2-amino-2, 3-dimethylbutyronitrile to 2-amino-2, 3-dimethylbutyramide in a biphasic system via an easily prepared whole-cell biocatalyst. Green Chemistry 17(7): 3992-3999.
  13. Ma, X., S. Deng., E. Su* and D. Wei* (2015). One-pot enzymatic production of deacetyl-7-aminocephalosporanic acid from cephalosporin C via immobilized cephalosporin C acylase and deacetylase. Biochemical Engineering Journal 95: 1-8.
  14. Ma, X., E. Su*., Y. Zhu., S. Deng and D. Wei* (2013). High-level expression of glutaryl-7-aminocephalosporanic acid acylase from Pseudomonas diminuta NK703 in Escherichia coli by combined optimization strategies. Journal of biotechnology 168(4): 607-615.




  1. K. Zhou., Ma, X. and H. Liang and (2017). Ligation and/or Assembly of Nucleic Acid Molecules. (PCT WO/2019/083,449).
  2. K. Zhou., Ma, X. and H. Liang and (2020). Ligation and/or Assembly of Nucleic Acid Molecule, (US Patent App. 16/758,933).


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Support by: Wei Cheng