报 告 人： 孙镇菲 农生学院植物科学系 副研究员

时    间：2025年5月28日 (星期三) 12:40-14:00

地    点： 农生学院B楼104会议室

主办单位：农生学院学科与科技办、农生学院青年教师联谊会

报告题目：长链非编码RNA（ LncRNA）协同调控光呼吸途径和开花途径的作用机制研究

报告摘要：

本研究针对光呼吸这一植物光合碳代谢的关键修复途径，揭示一长链非编码RNA（lncRNA）通过动态调控光呼吸核心酶——羟基丙酮酸还原酶（HPR1）的核质穿梭，介导光暗信号转换与开花时间的精准调控。该lncRNA作为分子支架，促进HPR1与转运蛋白的互作，在暗转光过程中通过调控HPR1的核输出，协调光呼吸效率与开花信号。并证明该机制在作物中高度保守，基于此理论，我们在玉米和马铃薯中成功鉴定了功能类似的lncRNA，并通过遗传改良显著提升了光合效率和产量。这一研究不仅阐明了光呼吸与发育调控的新关联，更为作物高产育种提供了创新的分子靶点与策略。

报告人简介：

报告人本科毕业于西北农林科技大学，博士毕业于中国农业大学。2011-2013年在中国科学院植物生理生态研究所从事博士后工作。以第一作者在Journal of Advanced Research、PLoS Genetics等期刊发表多篇研究论文。主持国家自然科学基金面上项目、国家自然科学基金青年项目等项目。

所在学科研究组研究方向：

1. 植物表观遗传学；
2. 非编码RNA功能解析。

ACADEMIC SALON (66)

SPEAKER: Zhenfei Sun

Associate researcher, Department of Plant Science, SAB

TIME ：12:40-14:00 May 28th, 2025 (Wed)

VENUE：Room 104, Building B, SAB

ORGANIZER：Office of Discipline and Science & Technology, SAB;

Young Teachers Association, SAB

TITLE： 

Coordinating Photorespiration and Flowering by a LncRNA-mediated Nuclear-cytoplasmic Partition of a Peroxisomal Enzyme

ABSTRACT：

The photorespiration is a metabolic repair system that enables the CO2 fixation enzyme Rubisco to operate sustainably in the presence of oxygen. Despite the extensive research on the biochemical processes of photorespiration, the cellular regulatory mechanisms of core enzymes involved in the photorespiration remain unexplored. Here we found that an Arabidopsis lncRNA, functions as a scaffold to mediate the interaction between the nuclear-cytoplasmic shuttle protein and hydroxypyruvate reductase (HPR1), a core enzyme in the photorespiration pathway. Notably, we observed that light/dark transitions induce the nuclear-cytoplasmic translocation of HPR1. Furthermore, lncRNA and the nuclear-cytoplasmic shuttle protein modulate the exporting of HPR1 out of nucleus during the transition from darkness to light, which is essential for the normal photorespiration process. Moreover, the nuclear HPR1and BLIL2 module regulates flowering by affecting the splicing of FLC sense transcript. Our findings reveal that lncRNA and the nuclear-cytoplasmic shuttle protein regulate the nuclear-cytoplasmic partition of HPR1, thus coordinate the photorespiration and flowering pathways.