时 间:2023年10月25日 (星期三) 12:40-14:00
地 点:农生学院创新楼(B楼)104会议室
主办单位:农生学院学科与科技办、农生学院青年教师联谊会
报告题目:可编程核酸纳米材料介导的RNA递送研究
报告摘要:
针对植物学领域中存在的外源分子递送瓶颈问题,开发了一系列基于可编程核酸材料的通用载体,将siRNA成功递送至植物细胞中并发挥相应生物学功能,成功攻克了该瓶颈问题;在此基础上,深入系统的研究了纳米载体与植物组织、细胞的相互作用,阐明了影响纳米载体有效进入植物细胞的两个重要因素。发现了植物体系RNA递送的新机制,为植物体制中纳米载体的设计提供了理论依据和技术支持。
报告人简介:
张欢博士2014年在中科院上海应用物理研究所获得博士学位。博士毕业后先后在中科院上海高等研究院、加州大学伯克利分校从事科学研究。2022年加入上海交通大学农业与生物学院,独立PI,博士生导师。主要研究方向为纳米技术介导的植物体系功能分子递送、植物传感检测及成像,以第一及通讯作者(含共同)在Nature Nanotechnology, PNAS, Nature Communications, Nature Protocols, Matter等国际刊物上发表论文20余篇。主持国家重点研发项目子课题、国家自然科学基金、军科委国防科技,上海市浦江人才等项目。担任Frontiers in Genome Editing客座编辑,多个期刊审稿人,受邀在国内外会议上做学术报告。
【所在学科研究组研究方向】:
1)可编程核酸材料的精密设计和可控自组装;
2)纳米探针开发及植物体系传感和成像应用;
3)纳米技术介导的植物体系基因编辑、功能分子递送和疾病治疗。
【代表性著作】:
1. Huan Zhang#, Natalie S Goh#, Jeffrey Wang, Gozde S Demirer, Salwan Butrus, So-Jung Park, Markita Landry*. Nanoparticle Cellular Internalization is Not Required for RNA Delivery to Mature Plant Leaves. Nature Nanotechnology, 2022, 17, 197-205.
2.Huan Zhang#, Yuhong Cao#, Dawei Xu, Natalie S Goh, Gozde S Demirer, Stefano Cestellos-Blanco, Yuan Chen, Markita P. Landry*, Peidong Yang*. Gold Nanocluster Mediated Delivery of siRNA to Intact Plant Cells for Efficient Gene Knockdown. Nano Letters, 2021, 21, 5859–5866.
3. Huan Zhang#, Honglu Zhang#, Gozde S. Demirer, Eduardo González-Grandío, Chunhai Fan and Markita P. Landry*. Engineering DNA nanostructures for siRNA delivery in plants. Nature Protocols, 2020, 15, 3064-3087.
4. Huan Zhang#, Gozde S. Demirer#, Honglu Zhang#, Tianzheng Ye, Natalie S. Goh, Abhishek J. Aditham, Francis J. Cunningham, Chunhai Fan and Markita P. Landry*. DNA Nanostructures Coordinate Gene Silencing in Mature Plants. PNAS, 2019,116, 15:7543-7548.
5. Yao Hu#, Zhongxu Luo#, Zhilei Ge, Qian Li, Peihui Yang, Honglu Zhang*and Huan Zhang* (2023). Morphology Dictated Immune Activation with Framework Nucleic Acids. Small, 2023, 23034: 1-10.
ACADEMIC SALON (XLIV)
SPEAKER: Huan Zhang
Associate Professor, Department of Plant Science, SAB
TIME :12:40-14:00 October 25th, 2023 (Wed)
VENUE:Room 104, Building B, SAB
ORGANIZER:Office of Discipline and Science & Technology, SAB;
Young Teachers Association, SAB
TITLE: Research on RNA delivery mediated by programmable nucleic acid nanomaterials.
ABSTRACT:A series of programmable nucleic acid-based universal vectors have been developed to address the bottleneck issue of delivering exogenous molecules in the field of plant biology. These vectors have successfully delivered siRNA to plant cells and exerted corresponding biological functions, overcoming the aforementioned bottleneck. Building upon this achievement, in-depth and systematic research has been conducted on the interactions between nanocarriers and plant tissues/cells. Two important factors influencing the effective entry of nanocarriers into plant cells have been elucidated. A novel mechanism for RNA delivery in plant systems has been discovered, providing theoretical basis and technical support for the design of nanocarriers in plant systems.
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