授课人：王应祥， 复旦大学 研究员

时间：12月6日，星期一，18:00-20:20

地点：陈瑞球楼219

授课教师简介

2002-2007华南农业大学，获博士学位

2007-2009华南农业大学，博士后

2009-2011复旦大学，博士后

2011.07至今  复旦大学, 副研究员 研究员

2016教育部“青年长江学者”

2019国家自然科学“杰出青年”基金资助，复旦大学“卓识杰出人才”资助

研究领域

减数分裂直接影响动物生殖和作物育性与产量。王应祥研究员长期从事减数分裂分子机制研究，取得的主要成果包括：1）揭示了4个DNA复制因子在减数分裂重组中的功能，提出包括DNA后随链合成的重组模型；2）发现了一类减数分裂细胞特异的小RNA，揭示了重组依赖的小RNA与重组位置分布的关联性；3）阐明了减数分裂特异特异染色体浓缩进程的表观遗传调控机制。迄今在Annual Review Plant Biology、Nature Plant、Plant Cell、PNAS等杂志共发表SCI论文和综述41篇。

代表性论文

1. Li X, Zhang J, Huang J, Xu J, Chen Z, Copenhaver GP, Wang YX*. Regulation of interference-sensitive crossover distribution ensures crossover assurance in Arabidopsis. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47): e2107543118.
2. Chen H, He C, Wang C, Wang X, Ruan F, Yan J, Yin P, Wang YX*, Yan S*. RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis. Plant Cell. 2021 Aug 31;33(8):2869-2882.
3. Li X, Yu MS, Bolaños-Villegas P, Zhang J, Ni DA, Ma H, Wang YX*. Fanconi Anemia Ortholog FANCM Regulates Meiotic Crossover Distribution in Plants. 2021, Plant Physiology. 186(1):344-360.
4.  Wang J#, Yu CY#, Zhuang SB, Ye JY, Dai H, Wang HK, Huang JY, Cao XF, Ma JB*, Ma H*, Wang YX*. Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis. Nature Plants, 2020, 10.1038/s41477-020-0697-0.
5. Wang HK#, Xu WY#, Sun YJ, Lian QC, Wang C, Yu CY, He CP, Wang J, Ma H, Copenhaver GP*, Wang YX*. The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants. PLOS Genetics, 2020, doi.org/10.1371/journal.pgen.1008849.
6. Huang JY#, Wang C#, Li X, Fang XL, Huang N, Wang Y, Ma H, Wang YX*, Copenhaver GP*. Conservation and divergence in the meiocyte sRNAomes of Arabidopsis, soybean and cucumber. Plant Physiology, 2020, 82:301-317.
7. Xu RY#, Xu J#,  Wang LD#, Niu BX, Copenhaver GP, Ma H, Zheng BL, Wang YX*. The Arabidopsis anaphase promoting complex/cyclosome subunit 8 is required for male meiosis. New Phytologist, 2019, 224(1):229-24.
8. Huang JY#, Wang C#, Wang HF, Lu PL, Zheng BL, Ma H, Copenhaver GP, Wang YX*. Meiocyte-specific and AtSPO11-1-dependent small RNAs and their association with meiotic gene expression and recombination. Plant Cell, 2019, 31:1-21. In brief by the editor in the same issue.
9. Xue M#, Wang J#, Jiang LG, Wolfe S, Pawlowskic WP*, Wang YX*, He Y* (2018) The number of meiotic double-strand breaks influences crossover distribution in Arabidopsis. Plant Cell, 2018, 30: 2628-2638.
10. Wang Y*, Copenhaver GP*. Meiotic Recombination: Mixing It Up in Plants. Annual Review Plant Biology. 2018, 69: 577-609.
11. Su H#, Chen ZH#, Huang JY, Lin J, Copenhaver GP, Ma H, Wang YX*. Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination. PLOS Genetics, 2017, e1006827. doi: 10.1371.
12. Wang J, Niu BX, Huang JY, Wang HK, Yang XH, Dong AW, Mackaroff C, Ma H, Wang YX*. Arabidopsis MMD1 Ensures the Progression of Male Meiotic Chromosome Condensation and Directly Regulates the Expression of Condensin Gene CAP-D3. Plant Cell. 2016, 28:1894-1909.
13. Niu BX#, Wang LD#, Zhang LS, Ren D, Ren R, Copenhaver GP, Ma H*, Wang YX*. The Arabidopsis CDC20.1 Gene is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation. Plant Cell. 2015, 27:1-16.
14. Huang JY#, Cheng ZH#, Wang C, Hong Y, Su H, Wang H, Copenhaver GP, Ma H*, Wang YX*. Formation of interference-sensitive meiotic crossovers requires sufficient DNA leading strand elongation. PNAS, 2015, 112:12534-9.