王哲 职    称：长聘教轨副教授，独立课题组长，博士生导师 所属学科：动物科学系 研究方向：人兽共患病原微生物学和系统生物学 电子信箱：wangz@sjtu.edu.cn 联系地址：上海交通大学农业与生物学院0-310室 邮编: 200240

个人和课题组简介：

王哲，2002年本科毕业于西安交通大学生命科学与技术学院，获工学学士学位。2008年毕业于北京大学生命科学学院，获理学博士学位。2008至2013年，分别在复旦大学生物医学研究院和美国康奈尔大学人类生态学院接受博士后训练。2013年起，在美国康奈尔大学医学院传染病科学系任副研究员，至2020年回国加入上海交通大学农业与生物学院动物科学系。

分枝杆菌是对人类和动物危害较大的一类致病性细菌。其中，结核分枝杆菌与非结核分枝杆菌感染病例，在我们国家一直居高不下。与此同时，现有抗生素耐药性的普遍出现，以及缺乏新型抗生素等问题日趋严重。我们课题组将综合运用病原微生物学、免疫学、群体遗传学、基因组学、代谢组学和药物化学等手段，重点关注以下几个方向：

1. 致病性分枝杆菌能量代谢通路关键基因的进化与功能分析。

2. 病原体-宿主之间互作的分子机制解析。

3. 新型抗细菌药物的开发以及耐药性机理的研究。

4. 新型快速精准疾病诊断技术的开发。

 

课题组成员：

王龙龙 2020级博士研究生

马世伟 2020级硕士研究生

 

科研项目：

目前主持国家自然科学基金面上项目1项，曾经主持青年基金等国家级和省部级项目4项。

 

论文论著：(*=共同第一作者， #=通讯作者)

1. Joanna C. Evans, Dinakaran Murugesan, John M. Post, Vitor Mendes, Zhe Wang, Navid Nahiyaan, Sasha L. Lynch, Stephen Thompson, Simon R. Green, Peter C. Ray, Jeannine Hess, Christina Spry, Anthony G. Coyne, Chris Abell, Helena I. M. Boshoff, Paul G. Wyatt, Kyu Y. Rhee, Tom L. Blundell, Clifton E. Barry III, Valerie Mizrahi. Targeting Mycobacterium tuberculosis CoaBC through chemical inhibition of 4’-phosphopantothenoyl-L-cysteine synthetase (CoaB) activity. 2021, Published Ahead-of-Print, ACS Infectious Diseases

2. Xiaoqiang Shi and Zhe Wang#. The current advances and future perspectives of lateral flow immunoassay for infectious diseases. 2021, Published Ahead-of-Print, Reviews in Medical Microbiology

3. Vitor Mendes, Simon R Green, Joanna C Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H Chan, Pedro H M Torres, Zhe Wang, Navid Nahiyaan, Sandra O'Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L Lynch, Anthony G Coyne, Peter C Ray, Chris Abell, Kyu Y Rhee, Helena I M Boshoff, Clifton E Barry 3rd, Valerie Mizrahi, Paul G Wyatt, Tom L Blundell. Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site. 2021,12(1):143, Nature Communications

4. Guillem Santamaria, Chen Liao, Zhe Wang, Kyu Rhee, Francisco Pinto, Jinyuan Yan, Joao B. Xavier. Metabolic homeostasis controls the diversity of cooperative swarming in pathogenic bacteria. 2020, bioRxiv

5. Zhe Wang, Vijay Soni, Gwendolyn Marriner, Takushi Kaneko, Helena I. M. Boshoff, Clifton E. Barry III, Kyu Rhee. Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M.tuberculosis to bedaquiline. 2019, 16 (39), Proceedings of the National Academy of Sciences (PNAS)

6.  Xiaoxian Guo, Ruoyu Zhang, Yudong Li, Zhe Wang, Olena P. Ishchuk, Khadija M. Ahmad d Josephine Wee, Jure Piskurd, Joshua A. Shapiro, Zhenglong Gu. Understand the Genomic Diversity and Evolution of Fungal Pathogen Candida glabrata by Genome-wide Analysis of Genetic Variations. 2019, Methods

7. Xiaoyun Lu, Zoe Williams, Kiel Hards, Jian Tang, …, Zhe Wang, Kyu Rhee, Kevin Pethe, Ke Ding, Gregory M. Cook. A pyrazolo[1,5-a]pyridine inhibitor of QcrB for the treatment of drug-resistant Tuberculosis. 2019,5(2):239-249. ACS Infectious Diseases

8. Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi…, Zhe Wang…Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland. Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA, 2018, 9(6). mBio

9. Zhe Wang*#, Xuepeng Sun*, Josephine Wee, Xiaoxian Guo, Zhenglong Gu#. Novel Insights into Global Translational Regulation through Puf3p Revealed by Ribosomal Profiling, 2018, 1-12, Current Genetics

10. Xavier Carette, John Platig, David C. Young, Michael Helmel, Albert T. Young, Zhe Wang,…Kyu Y. Rhee, D. Branch Moody, Hanno Steen, Robert N. Husson. Multi-systems analysis of Mycobacterium tuberculosis reveals kinase-dependent remodeling of the pathogen-environment interface, 2018, 9 (2), mBio

11. Zhe Wang# and Zhenglong Gu. Chapter 12: Novel insights of the gene translational dynamic and complex revealed by Ribosome Profiling. 2018, 239-256, ISBN: 978-3-319-92967-5, In Book: Systems Biology. Editor: Jan Barciszewski. Springer Nature publishing

12. Zhe Wang# and Ai Ni#. Chapter 2: Use Data Ming and Machine Learning Approaches to Combat Human Diseases: Amyotrophic Lateral Sclerosis (ALS) as an Example. 2018, 47-82, ISBN: 978-1-53613-327-1, In Book: Horizons in Computer Science Research. Volume 16. Editor: Thomas S. Clary. NOVA science publishers

13. Irnov Irnov, Zhe Wang, Nicholas D. Jannetty, Julian A. Bustamante, Kyu Y. Rhee, Christine Jacobs-Wagner. Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate, 2017, 13 (8), PLoS Genetics

14. Zhe Wang#. Plant-derived antifungal compounds trigger a common transcriptional response, 2017, 54, 1-3, Infection, Genetics and Evolution

15. Kerry E. Boyle, Hilary T. Monaco, Maxime Deforet, Jinyuan Yan, Zhe Wang, Kyu Rhee and Joao Xavier. Metabolism and the evolution of social behavior, 2017, 34(9):2367-2379, Molecular Biology and Evolution

16. Hyungjin Eoh, Zhe Wang, Emilie Layre, Poonam Rath, Roxanne Morris, D. Branch Moody, Kyu Rhee. Metabolic anticipation in Mycobacterium tuberculosis, 2017, 2, 17084, 1-7, Nature Microbiology

17. Susan Puckett, Carolina Trujillo, Zhe Wang, Hyungjin Eoh, Thomas R. Ioerger, Inna Krieger, James Sacchettini, Dirk Schnappinger, Kyu Y Rhee, Sabine Ehrt. Glyoxylate detoxification: An essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis, 2017, 114（11）2225-2232, Proceedings of the National Academy of Sciences (PNAS)

18. Zhe Wang# and Yan Shen. The natural product osthole attenuates yeast growth by extensively suppressing the gene expressions of mitochondrial respiration chain, 2017, 74 (3), 389-395, Current Microbiology

19. David J. Samuels, Zhe Wang, Kyu Y. Rhee, Shaun R. Brinsmade. A tandem liquid chromatography-mass spectrometry-based approach for metabolite analysis of Staphylococcus aureus, 2017, 121, Journal of Visualized Experiments

20. Travis E. Hartman, Zhe Wang, Robert S. Jansen, Susana Hartmann, Kyu Y. Rhee. Metabolic Perspectives on Persistence. 2017, 5 (1), Microbiology Spectrum

21. Zhe Wang#. Big Data Mining Powers Fungal Research: Recent Advances in Fission Yeast Systems Biology Approaches. Invited review article. 2017, 63(3):427-433, Current Genetics

22. Yumi Park, Angela Pacitto, Tracy Bayliss, Laura A. T. Cleghorn, Zhe Wang, Travis Hartman, Kyu Rhee…..Clifton E. Barry 3rd, and Helena I.M. Boshoff. Essential but not vulnerable: imidazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis. 2017, 3(1), 18-33, ACS Infectious Diseases

23. Joanna C. Evans, Carolina Trujillo, Zhe Wang, Hyungjin Eoh, Sabine Ehrt, Dirk Schnappinger, Helena I.M. Boshoff, Kyu Y. Rhee, Clifton E. Barry 3rd, Valerie Mizrahi. Validation of CoaBC as a bactericidal target in the coenzyme A pathway of Mycobacterium tuberculosis. 2016, 2 (12), 958–968, ACS Infectious Diseases

24. Zhe Wang# and Yan Shen. Antifungal compound honokiol triggers oxidative stress responsive signaling pathway and modulates central carbon metabolism. 2016, 7 (3), 124-133, Mycology

25. Zhe Wang*#, Zhongkai Gu*, Yan Shen, Yang Wang, Jing Li, Hong Lv#, and Keke Huo#. The Natural Product Resveratrol Inhibits Yeast Cell Separation by Extensively Modulating the Transcriptional Landscape and Reprogramming the Intracellular Metabolome. 2016, 11(3), PLoS One

26. Xuepeng Sun*, Zhe Wang*, Xiaoxian Guo, Hongye Li, Zhenglong Gu. Coordinated Evolution of Transcriptional and Post-transcriptional Regulation for Mitochondrial Functions in Yeast Strains. 2016, 11(4), PLoS One

27. Zhe Wang*, Xuepeng Sun*, Xiaoxian Guo, Huifeng Jiang, Zhenglong Gu. Evolution of gene regulation during transcription and translation. 2015, 7 (4), 1155-1167, Genome Biology and Evolution

28. Huifeng Jiang, Lin Xu, Zhe Wang, Jack Keene, Zhenglong Gu. Coordinating Expression of RNA Binding Proteins with Their mRNA Targets. 2014, 24 (4), 7175, Scientific Reports

29. Wenxia Sun*, Zhe Wang*, Hengyi Jiang, Jing Zhang, Jurg Bahler, Dongrong Chen, Alastair I. H. Murchie. A novel function of the mitochondrial transcription factor Mtf1 in fission yeast; Mtf1 regulates the nuclear transcription of srk1. 2011, 39(7), 2690-700, Nucleic Acids Research

30. Hengyi Jiang*, Wenxia Sun*, Zhe Wang*, Jing Zhang, Dongrong Chen, Alastair I. H. Murchie. Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe. , 2011, 39(12) 5119-30, Nucleic Acids Research 

31. Yan Shen, Zhe Wang, Dongrong Chen. The mechanism of thiopeptin antibiotics resistance-research on the biochemical properties of 23S rRNA methyltransferase. 2011, 38(3), 189-93. Fudan University Journal of Medical Sciences

32. Huirong Yang*, Zhe Wang*, Yan Shen*, Ping Wang*, Xu Jia, Liang Zhao, Pei Zhou, Rui Gong, Ze Li, Ying Yang, Dongrong Chen, Alastair I. H. Murchie Yanhui Xu. Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus. 2010, 49(30), 6440-50, Biochemistry

33. Yang Wang, Zhe Wang, Yan Shen, Dongrong Chen. Inhibition effect of Lycorine on the growth of Saccharomyces Pombe. 2010, 37(6), 642-46. Fudan University Journal of Medical Sciences

34. Zhe Wang*, Guangyu Cao*, Xinlei Wang, Jin Miao, Xiaoting Liu, Zhangliang Chen, Li-Jia Qu, Hongya Gu. Identification and characterization of COI1-dependent transcription factor genes involved in JA-mediated response to wounding in Arabidopsis plants. 2008, 27(1), 125-35. Plant Cell Reports

35. Xiaoyan Mo, Jing Li, Ning Feng, Zhe Wang, Dexia Yang, Genggeng Gao. Analysis on the Vitamin C Contents in Two Major Species of Bamboo Leaves for Captive Qinling Giant Panda. 2004, 23(2), 62-66. Journal of Food Science and Biotechnology

 

申请专利：

1. 发明人：王哲; 一种基于流体控制的CRP/MxA联合检测试剂盒, 2020-7-21, 中国, 201920715111.9.   

2. 发明人：王哲; 基于流体控制的侧向层析检测装置和试剂盒, 2019-5-19, 中国, 201910416127.4.