学术沙龙

学术沙龙第四期:Application of Metabolomics in Combating Mycobacterium Infection

发布时间:2020-12-17  阅读次数:2200

报 告 人:王哲   农生学院动物科学系 长聘教轨副教授 博导 独立PI

   间:2020年12月23日 (星期三) 13:30-14:15

   点:农生学院创新楼(B楼)104会议室

主办单位:农生学院学科与科技办、农生学院青年教师联谊会

 

 

报告题目:

Application of Metabolomics in Combating Mycobacterium Infection

报告摘要:

分枝杆菌属包括许多能对哺乳动物造成严重疾病的病原菌。其中,结核分枝杆菌能够感染人类和动物,引发结核病。我们国家目前仍属于结核病流行最为严重的国家之一。同时,抗生素滥用造成的耐药性问题逐年加重,因此对于新型抗生素的需求也愈发迫切。代谢组学是一种正在得到广泛应用的新型组学技术。在实践中,它能够帮助我们从系统生物学的视角理解分枝杆菌“生长缓慢、潜伏期长、抗逆性强”的独特生理特征。同时,在抗菌药物开发过程中,可以协助我们更快速地确定新型药物靶标、理解药物作用和耐药性发生的机理,以及寻找更为有效的药物组合方案。

报告人简介:

【PI学科组研究方向】:

分枝杆菌是对人类和动物危害较大的一类致病性细菌。其中,结核分枝杆菌与非结核分枝杆菌感染病例在我们国家仍居高不下。与此同时,现有抗生素耐药性的普遍出现,以及缺乏新型抗生素的问题日趋严重。我们课题组将综合运用病原微生物学、免疫学、群体遗传学、基因组学、代谢组学和药物化学等手段,重点关注以下几个方向:

1. 致病性分枝杆菌能量代谢通路关键基因的进化与功能分析。

2. 病原体-宿主之间互作的分子机制解析。

3. 新型抗细菌药物的开发以及耐药性机理的研究。

4. 新型快速精准疾病诊断技术的开发。

 

【代表性著作】: 

1. Zhe Wang, Vijay Soni, Gwendolyn Marriner, Takushi Kaneko, Helena I M Boshoff , Clifton E Barry 3rd, Kyu Y Rhee. 2019. Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline. PNAS, 116(39):19646-19651.

2. Zhe Wang, Xuepeng Sun, Yi Zhao, Xiaoxian Guo, Huifeng Jiang, Hongye Li, Zhenglong Gu. 2015. Evolution of gene regulation during transcription and translation. Genome Biology and Evolution. 7(4):1155-1167.

 

 

ACADEMIC SALON (IV)

SPEAKER: Zhe Wang

Tenure-track Associate Professor, Ph.D. Supervisor, PI

Department of Animal Science, SAB

TIME :13:30-14:15 Dec 23, 2020 (Wed)

VENUE:Room 104, Building B, SAB

ORGANIZER:Office of Discipline and Science & Technology, SAB;

Young Teachers Association, SAB

TITLE:Application of Metabolomics in Combating Mycobacterium Infection.

ABSTRACT:

Mycobacteria genus includes many bacterial pathogens that can cause serious diseases in mammals. Among them, Mycobacteria tuberculosis can infect human and animal, causing tuberculosis (TB). China is still one of the countries with the worst TB epidemics. Meanwhile, the problem of drug resistance caused by antibiotic abuse is increasing year by year, therefore the demand for novel antibiotics is becoming more and more urgent. Metabolomics is one of the newest Omics techniques, and it is being widely used now. Particularly, it can help us understand mycobacteria's unique physiological characteristics of "slow growth, long non-replication phase, and strong resistance" from the perspective of system biology. At the same time, metabolomics approach can assist us in antimicrobial discovery through more quickly identifying novel drug targets, understanding the mechanisms of drug action and resistance, and finding more effective drug combinations.

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