按PI研究组

PI组长:

陈诚 长聘教轨副教授

研究方向:

细胞器生物学

主要研究领域:

叶绿体(质体)是绿色植物所特有的一类细胞器,是光合作用发生的场所。植物在生长、发育过程中,叶绿体的数量需要随之增加以适应植物不断增长的物质、能量需求,并确保细胞分裂所形成的子细胞中都能继承到相近数量的此种细胞器。叶绿体数量的增加主要是通过叶绿体分裂实现的。

本课题组拟综合运用分子生物学、细胞生物学、遗传学、生物化学以及合成生物学等相关技术、手段开展植物生长、发育过程中,叶绿体、线粒体、过氧化物酶体等重要功能细胞器分裂调控分子机制的研究。

PI研究组代表性成果:

1、主要研究项目:

结合前期的研究基础,本课题组未来将重点聚焦以下几个研究方向:

(1)叶绿体分裂的分子机理。将以拟南芥等模式系统为研究对象,解析叶绿体分裂装置组装、定位及动态变化的分子调控机制。

(2)细胞器与细胞分裂过程相互协调的分子机制。将首先从叶绿体细胞器入手,探究植物协调细胞分裂与细胞器分裂这两个紧密相连的生命过程的分子机理。

(3)淀粉体等非绿色质体的发生、分裂和分化的调控机制。淀粉体是非绿色质体中的一种,主要负责在细胞内长期储存淀粉。淀粉体主要存在于植物的根,种子胚乳(例如大米、小麦和玉米),块茎(例如马铃薯)和块根(例如红薯和木薯)等。淀粉体等非绿色质体相关的研究工作不仅具有重要的科学意义,同时也具有重大的农业和经济价值。

 

2、代表论著:

(1)Sun, T., Yuan, H., Chen, C., Kadirjan-Kalbach, D.K., Mazourek, M., Osteryoung, K.W. and Li, L., 2020. ORHis, a natural variant of OR, specifically interacts with plastid division factor ARC3 to regulate chromoplast number and carotenoid accumulation. Molecular plant13(6), 864–878. (SCI, IF = 12.7)

(2)Chen, C.#, Cao, L., Yang, Y., Porter, K. and Osteryoung, K.W.# (2019). ARC3 Activation by PARC6 Promotes FtsZ-Ring Remodeling at the Chloroplast Division Site. The Plant Cell 31, 862–885. (#corresponding author; SCI, 5-Year IF = 9.8)

(3)Kadirjan-Kalbach, D.K., Turmo, A., Wang, J., Smith, B., Chen, C., Childs, K., DellaPenna, D. and Osteryoung, K.W. (2019). Allelic Variation in the Chloroplast Division Gene FtsZ2-2 Leads to Natural Variation in Chloroplast Size. Plant Physiology, DOI: https://doi.org/10.1104/pp.19.00841 (SCI, 5-Year IF = 7.0) (Highlighted by Plant Physiology, DOI: https://doi.org/10.1104/pp.19.01159)

(4)Chen, C., MacCready, J.S., Ducat, D.C. and Osteryoung, K.W. (2018). The Molecular Machinery of Chloroplast Division. Plant Physiology 176(1), 138–151. (SCI, 5-Year IF = 7.0)

(5)Pan, R., Satkovich, J., Chen, C. and Hu, J. (2018). The E3 Ubiquitin Ligase SP1-Like 1 Plays a Positive Role in Peroxisome Protein Import in Arabidopsis. The Plant Journal 94(5), 836–846. (SCI, 5-Year IF = 6.5)

(6)TerBush, A.D., MacCready, J.S., Chen, C., Ducat, C.D. and Osteryoung, K.W. (2018). Conserved Dynamics of Chloroplast Cytoskeletal FtsZ Proteins Across Photosynthetic Lineages. Plant Physiology 176, 295–306. (SCI, 5-Year IF = 7.0)

(7)Zhang, M.*, Chen, C.*, Froehlich, J.E., Terbush, A.D. and Osteryoung, K.W. (2016). Roles of Arabidopsis PARC6 in Coordination of the Chloroplast Division Complex and Negative Regulation of FtsZ Assembly. Plant Physiology 170(1), 250–262. (*equal contribution; SCI, 5-Year IF = 7.0)

(8)Yoo, S.-C., Chen, C., Rojas, M., Daimon, Y., Ham, B.-K., Araki, T. and Lucas, W.J. (2013). Phloem Long-distance Delivery of FLOWERING LOCUS T (FT) to the Apex. The Plant Journal 75, 456–468. (SCI, 5-Year IF = 6.5)

(9)Chen, C., Zhang, Y., Zhu, L. and Yuan, M. (2010). The Actin Cytoskeleton Is Involved in the Regulation of the Plasmodesmal Size Exclusion Limit. Plant Signaling & Behavior 5:12, 1663–1665.

(10)Su, S.*, Liu, Z.*, Chen, C.*, Zhang, Y., Wang, X., Zhu, L., Miao, L., Wang, X., C. and Ming, Y. (2010). Cucumber Mosaic Virus Movement Protein Severs Actin Filaments to Increase the Plasmodesmal Size Exclusion Limit in Tobacco. The Plant Cell 22, 1373–1387. (*equal contribution; SCI, 5-Year IF = 9.8) 

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