PI组长：
       王旭  长聘教轨副教授

研究方向：
       植物线粒体应激机制

主要研究领域：

运用分子生物学、系统生物学等方法，解析与线粒体密切相关的抗逆、衰老和发育等相关表型。前期研究工作第一次揭示了线粒体未折叠蛋白反应 (mitochondrial unfolded protein response, UPR^mt) 调节植物细胞适应线粒体逆境的过程及调节机制。

PI研究组代表性成果：

1、主要研究项目：

目前实验室综合应用系统生物学、细胞生物学、遗传学等手段研究线粒体与细胞核及其他细胞器互作机制，重点关注以下几个主要方向：

       (1) 植物发育及逆境中的细胞器互作与线粒体逆向信号

       (2) 线粒体来源信号调节细胞与个体衰老的机制

       (3) 系统生物学在植物线粒体研究中的应用

2、代表论著：

1. Li H^#, Wang X^#, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Sleiman MB, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J. An integrated systems genetics and omics toolkit to probe gene function. Cell Systems 2018; 6: 90-102. (IF=8.640)

2. Wang X & Auwerx J. Systems phytohormone responses to mitochondrial proteotoxic stress. Molecular Cell 2017; 68: 540-51. (IF=14.548)

3. Stein S^#, Lemos V^#, Xu P, Demagny H, Wang X, Ryu D, Jimenez V, Bosch F, Lüscher TF, Oosterveer MH, Schoonjans K. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. Journal of Clinical Investigation. 2017; 127(2):583-592. (IF=12.282)

4. Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016; 352(6292):1436-43. (IF=41.037)

5. Moullan N^#, Mouchiroud L^#, Wang X, Ryu D, Williams EG, Mottis A, Jovaisaite V, Frochaux MV, Quiros PM, Deplancke B, Houtkooper RH, Auwerx J. Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research. Cell Reports. 2015; 10(10): 1681–91. (IF=7.815)

6. Jo YS^#, Ryu D^#, Maida A, Wang X, Evans RM, Schoonjans K, Auwerx J. Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. Hepatology. 2015; 62(5):1606-18. (IF=14.971)

7. Wang X^#, Ryu D^#, Houtkooper RH, Auwerx J. Antibiotic use and abuse: a threat to mitochondria and chloroplasts with impact on research, health, and environment. BioEssays 2015; 37(10):1045-53. (IF=4.396)

8. Wang X^#, Bian Y^#, Cheng K, Gu LF, Ye M, Zou H, Sun SSM, He JX. A Large-scale protein phosphorylation analysis reveals novel phosphorylation motifs and phosphoregulatory networks in Arabidopsis. Journal of Proteomics 2013; 78:486-98. (IF=3.537)

9. Wang YD^#, Wang X^#, Ngai SM, Wong YS. Comparative proteomics analysis of selenium responses in selenium-enriched rice grains. Journal of Proteome Research 2013; 12:808-20. (IF=3.780)

10. Wang YD^#, Wang X^#, Wong YS. Generation of selenium-enriched rice with enhanced grain yield, selenium content and bioavailability through fertilisation with selenite. Food Chemistry 2013; 141:2385-93. (IF=5.399)

11. Wang X, Bian Y, Cheng K, Zou H, Sun SSM, He JX. A comprehensive differential proteomic study of nitrate deprivation in Arabidopsis reveals complex regulatory networks of plant nitrogen responses. Journal of Proteome Research 2012; 11:2301-15. (IF=3.780)

12. Wang YD^#, Wang X^#, Wong YS. Proteomics analysis reveals multiple regulatory mechanisms in response to selenium in rice. Journal of Proteomics 2012; 75:1849-1866. (IF=3.537)

# 共同第一作者。

完整论文列表：https://www.ncbi.nlm.nih.gov/sites/myncbi/1bszwXerzLSQC/bibliography/41587948/public/?sort=date&direction=descending