报 告 人：余 祥    上海交通大学生命科学技术学院 遗传与发育科学系长聘教轨副教授

时    间：2021年6月16日 (星期三) 12:40-14:00

地    点：农生学院创新楼（B楼）104会议室

主办单位：农生学院学科与科技办、农生学院青年教师联谊会

 

 

报告题目：RNA代谢和化学修饰调控植物发育和逆境适应的分子机制

报告摘要：

RNA代谢和化学修饰是生命体中两种重要且保守的转录后调控方式，在多细胞生物的发育和环境应激中扮演着不可或缺的角色。RNA代谢主要通过多种途径的RNA降解来精细控制RNA的质量和数量。近年发现编码基因的信使RNA存在多种表观遗传修饰，这些化学修饰通过介导mRNA的折叠、转运和降解影响RNA的生命周期和翻译活性。报告人课题组采用分子生物学和组学技术等手段、围绕植物RNA生物学展开研究。本报告将重点介绍两种新颖的植物RNA转录后调控途径——翻译偶联的RNA降解(co-translational RNA decay)和RNA 5’端帽子修饰 (NAD⁺ capping)， 以及探讨它们对植物发育和逆境适应的生物学功能。

 

报告人简介：

报告人2014年在中国科学院上海生命科学学院植物生理生态研究所获博士学位，2014-2021年在美国宾夕法尼亚大学文理学院生物系进行博士后研究，2021年2月入职上海交通大学生命科学技术学院。

【PI学科组研究方向】：

余祥课题组主要开展植物逆境RNA生物学和组学技术方面的研究。主要研究方向如下：

1.RNA生物学:研究RNA转录和转录后调控的分子机制；

2.植物逆境生物学:研究RNA转录后调控如何参与植物应对非生物胁迫；

3.组学技术研发:结合分子生物学和高通量测序技术研发新的组学方法；

4.组学数据分析:开发程序对多组学数据进行整合分析。

【代表性著作】： 

1. Xiang Yu et al: Messenger RNA 5’ NAD⁺ capping is a dynamic regulatory epitranscriptome mark that is required for proper response to abscisic acid in Arabidopsis. Developmental Cell 01/2021; 56: 125-140.

2. Shuxia Li*, Xiang Yu* et al: Large-scale analysis of cassava transcriptome reveals the impact of cold stress on alternative splicing. Journal of Experimental Botany 1/2020; 71(1): 422-434 

3. Xiang Yu et al: Genome-Wide TOP2A DNA Cleavage is Biased Toward Translocated and Highly Transcribed Loci. Genome research 07/2017; 27 (7): 1238-1249.

4. Jun Xiao, Run Jin, Xiang Yu et al: Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis. Nature Genetics 10/2017; 49 (10): 1546.

5. Xiang Yu et al: Genome-Wide Mapping of Uncapped and Cleaved Transcripts Reveals a Role for the Nuclear mRNA Cap-Binding Complex in Co-translational RNA Decay in Arabidopsis. The Plant Cell 10/2016; 28 (10): 2385-2397.  

6. Xiang Yu et al: Identification of conserved and novel microRNAs that are responsive to heat stress in Brassica rapa. Journal of Experimental Botany 01/2012; 63(2):1025-38. 

 

 

ACADEMIC SALON (XIX)

SPEAKER: Xiang Yu

Tenure-track Associate Professor, PI

School of Life Sciences and Biotechnology, SJTU

TIME ：12:40-14:00  June 16, 2021

VENUE：Room 104, Building B, SAB

ORGANIZER：Office of Discipline and Science & Technology, SAB;

Young Teachers Association, SAB

TITLE：The function of RNA metabolism and modification in plant development and stress response

ABSTRACT：

RNA metabolism and RNA modification are two important post-transcriptional regulation pathways, which play critical role in plant development and response to multiple environmental stresses. RNA metabolism precisely controls the RNA quality and quantity through RNA degradation pathways. Recent studies uncovered that messenger RNAs can be regulated with multiple modifications such as m6A, m1A and m5C, which affect the RNA life cycle and RNA translation by mediating mRNA secondary structure, mRNA transport and mRNA degradation. Yu lab focuses on plant RNA biology using cutting edge molecular and Omics technology. In this seminar, Xiang Yu will introduce two novel plant post-transcriptional regulation pathways: co-translational RNA decay and RNA NAD+ capping and explore their potential functions in plant development and stress response.