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XU JIANXIONG

XU JIANXIONG

Professor
Department of Animal Science
Research Interests：Molecular Nutrition, Oxidative stress and health, Nutrition and Immunity
Phone：86-21-34205767
Email：jxxu1962@sjtu.edu.cn

 

Xu Jianxiong, Professor, doctoral supervisor, visiting scholar of NIH, and Shuguang Scholar of Shanghai. In recent years, he has been mainly engaged in Digestive tract development, immunity and nutrition regulation, and development of new plants ingredients. It has completed more than 30 projects such as National Natural Science Foundation, national key research and development plan project, published more than 120 papers in academic journals, won 3 second and 6 third prizes of provincial and ministerial science and Technology Progress Awards, won 1 first prize of Shanghai Excellent Invention, won 14 national patents, and transferred 9.

 

Awards

Second Prize of China Industry-University-Research Cooperation Innovation Achievement Award in 2018;

Second Prize of Shanghai Science and Technology Progress Award in 2017;

The second-class prize for advances of science and technology in Shanghai in 2006;

The third-class prize for advances of science and technology in Shanghai in 2002;

Shuguang scholar of Shanghai in 1997

 

Projects:

2023.1-2026.12 National Natural Science Foundation of China: Exploring the molecular mechanism of ergothioneine improving liver function and inflammatory response via regulation of mitophagy by miR-421/PINK1/NLRP3 pathway in weaned piglets

2021.07-2024.09 Shanghai modern seed industry collaborative innovation center cultivation project: Functional mining of NIPSNAP in intramuscular fat deposition and pork quality formation in pigs 

2019.1- 2022.12 National Natural Science Foundation of China: The mechanism of intestinal inflammation regulated by ROS-NLRP3 signaling pathway in weaned piglets and the regulation role of sausselene acid.

 

Publications:

  1. Luo Z, Yao J, Wang Z, Xu J*. 2023. Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives. Journal of Translational Medicine 21, 441. https://doi.org/10.1186/s12967-023-04286-1.
  2. Yifei Bai , Tingting Qiu , Bin Chen , Cheng Shen , Chengbing Yu , Zhen Luo , Jing Zhang , Weina Xu , Zilong Deng*, Jianxiong Xu*, Hongcai Zhang*.2023.Formulation and stabilization of high internal phase emulsions: Stabilization by cellulose nanocrystals and gelatinized soluble starch. Carbohydrate Polymers 312. 120693.
  3. Gao, Q.; Luo, Z.; Ma, S.; Yu,C.; Shen, C.;Xu, W.; Zhang, J.;Zhang,H.; Xu, J*.2023. Microbe-Derived Antioxidants Alleviate Liver and Adipose Tissue Lipid Disorders and Metabolic Inflammation Induced by High Fat Diet in Mice. International Journal of Molecular Sciences. 24, 3269.https://doi.org/10.3390/ijms24043269
  4. Luo Z, Gao Q, Li Y, Bai Y, Zhang J, Xu W, Xu J*.2022. Flammulina velutipes Mycorrhizae Attenuate High Fat Diet Induced Lipid Disorder, Oxidative Stress and Inflammation in the Liver and Perirenal Adipose Tissue of Mice. Nutrients, 14, 3830. https://doi.org/10.3390/nu14183830.
  5. Hongcai Zhang, Miaomiao Feng, Yapeng Fang, Yan Wu, Yuan Liu, Yanyun Zhao & Jianxiong Xu.2022.Recent advancements in encapsulation of chitosan-based enzymes and their applications in food industry. Critical Reviews in Food Science and Nutrition, 13:1-19.
  6. Shen C#, Luo Z#, Ma S, Yu C, Gao Q, Zhang M, Zhang H, Zhang J, Xu W, Yao J and Xu J*.2022. Microbe-Derived Antioxidants Reduce Lipopolysaccharide Induced Inflammatory Responses by Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1β Signaling Pathway. International Journal of Molecular Sciences, 23, 12477. https://doi.org/10.3390/ijms232012477.
  7. Luo Z, Gao Q, Zhang H, Zhang Y, Zhou S, Zhang J, Xu W, Xu J*.2022.Microbe-derived antioxidants attenuate cobalt chloride-induced mitochondrial function, autophagy and BNIP3-dependent mitophagy pathways in BRL3A cells. Ecotoxicology and Environmental Safety, 232113219.
  8. Ma S, Xu J*, Lai T, Xu W, Zhang J,Zhang H* and Zhang W* 2022. Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation. Frontiers in Nutrition. 9:934073.doi: 10.3389/fnut.2022.934073
  9. Hongcai Zhang*, Miaomiao Feng, Yapeng Fang, Yan Wu, Yuan Liu, Yanyun Zhao*, and Jianxiong Xu*.2022.Recent advancements in encapsulation of chitosan-based enzymes and their applications in food industry.Critical Reviews in Food Science and Nutrition https://doi.org/10.1080/10408398.2022.2086851
  10. Hongcai Zhang, Tingting Qiu, Yifei Bai , Bin Chen, Juan Yan, Jianxiong Xu*.2021. Enhanced antibacterial activity of lysozyme loaded quaternary ammonium chitosan nanoparticles functionalized with cellulose nanocrystals International Journal of Biological Macromolecules 191 :71-78
  11. Luo Z, Yao J, Xu J*. 2021.Reactive oxygen and nitrogen species regulate porcine embryo development during preimplantation period: A mini-review. Animal Nutrition, 7(3):823-828.
  12. Hongcai Zhang *, Siyu Wei , Juan Yan , Miaomiao Feng , Yifei Bai , Bin Chen , Jianxiong Xu *.2021. Development of double layer microcapsules for enhancing the viability of Lactobacillus casei LC2W in simulated gastrointestinal fluids. LWT-Food Science and Technology 145: 111319
  13. Luo,W.;Yin,X.;Yao,J.;Cheng,J.;Zhang,J.;Xu,W.;Mu,Y.;Xu,J*.2021.Fermented Soybean Meal Affects the Reproductive Performance and Oxidative Status of Sows, and the Growth of Piglets. Animals, 11,597. https://doi.org/10.3390/ani11030597
  14. Luo,W.;Li,L.;Xu,W.;Zhang,J.;Xu,J*.2021.Toxic Effects of Docosahexaenoic Acid Treatment in the Rat Liver BRL-3A Cell. Toxics 9, 112. https://doi.org/10.3390/toxics9050112
  15. Ma,S.;Zhang,H*.;Xu*,J.2021.Characterization,Antioxidant and Anti-Inflammation Capacities of Fermented Flammulina velutipes Polyphenols. Molecules, 26, 6205. https://doi.org/10.3390/molecules26206205
  16. Wenli Luo, Weina Xu, Jing Zhang, Jianbo Yao and Jianxiong Xu*.2020.The Maternal Diet with Fish Oil Might Decrease the Oxidative tress and Inflammatory Response in Sows, but Increase the usceptibility to Inflammatory Stimulation in their Offspring. Animals,10,1455;doi:10.3390/ani10091455
  17. Yu C, Zhang J, Qin Q, Liu J, Xu J, Xu W.2020. Berberine improved intestinal barrier function by modulating the intestinal microbiota in blunt snout bream (Megalobrama amblycephala) under dietary high-fat and high-carbohydrate stress, Fish and Shellfish Immunology ,doi: https://doi.org/10.1016/j.fsi.2020.04.052.
  18. Chen, X., T. Sho, W. Xu, J. Zhang and J. Xu*. 2019. Microbe-derived antioxidants promote the expression of nutrient transporters through regulating apoptosis and autophagy in mice challenged with diquat. Intl. J. Agric. Biol., 22:1155–1160
  19. Luo Z, Xu X, Sho T, Zhang J, Xu W, Yao J, Xu J*.2019. ROS-induced autophagy regulates porcine trophectoderm cell apoptosis, proliferation and differentiation. American Journal of Physiology-Cell Physiology, 316:2, C198-C209.
  20. Luo Z, Xu X, Sho T, Luo W, Zhang J, Xu W, Yao J, Xu J*. 2019.Effects of N-acetyl-cysteine in late gestational diet on maternal-placental redox status, placental NLRP3 inflammasome and fecal microbiota in sows. Journal of Animal Science, 97(4), 1757-1771.
  21. W. L. Luo , Z. Luo,X. Xu,S. Zhao,S. H. Li,T. Sho,J. Yao,J. Zhang,W. N. Xu,and J. X. Xu*.2019. The Effect of Maternal Diet with Fish Oil on Oxidative Stress and Inflammatory Response in Sow and New-Born Piglets. Oxidative Medicine and Cellular Longevity, Article ID 6765803, https://doi.org/10.1155/2019/6765803
  22. Wei-Na Xu & Dan-Hong Chen & Wen-Bin Liu & Jian-Xiong Xu.& Shuo-Shuo Yang .2018. Molecular characterization of Microtubule-associated protein 1-light chain 3 B in 2018 journal of applied genetics .59:345-355
  23. Q.Guo, Z.Luo, L.Zhu, X.Cai, C. Xu, J. Zhang, W. Xu & J. Xu*.2018. Weaning induced cell cycle arrest through up-regulation of p21 and p27 in the jejunum of piglets. S. Afr. J. Anim. Sci. 48：1099-1100
  24. Takami Sho JianXiong Xu∗.2018.Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation. Biotechnology and Applied Biochemistry.66,（1）4–13
  25. Zhen Luo, Wenli Luo, Shaohua Li, Sen Zhao, Takami Sho, Xue Xu, Jing Zhang, Weina Xu,Jianxiong Xu*.2018. Reactive oxygen species mediated placental oxidative stress, mitochondrial content, and cell cycle progression through mitogen-activated protein kinases in intrauterine growth restricted pigs. Reproductive Biology 18 :422–431
  26. Z. Luo, S. Yu1, Y. Zhu, J. Zhang, W. Xu.& J. Xu*.2018.Effect of various levels of isoflavone aglycone-enriched fermented soybean meal on redox status, serum hormones and milk quality in ewes. S. Afr. J. Anim. Sci. 48(4):673-682
  27. Luo Z, Zhu W, Guo Q, Luo W, Zhang J, Xu W, Xu J*. 2016.Weaning induced hepatic oxidative stress, apoptosis, and aminotransferases through MAPK signaling pathways in piglets. Oxidative Medicine and Cell Longevity, 9, 4768541.
  28. Xuan Cai, Lihui Zhu, Xiaolian Chen,Yongshuai Sheng, Qi Guo, Jian Bao &Jianxiong Xu*.2016.  X/XO or H2O2 induced IPEC-J2 cell as a new in vitro model for studying apoptosis in post-weaning piglets. Cytotechnology . 68:713–724
  29. Jianxiong Xu , Congcong, Xiaolian Chen, Xuan Cai,Shoufeng Yang, Yongshuai Sheng, Tian Wang*.2014.Regulation of an antioxidant blend on intestinal redox status and major microbiota in early weaned piglets. Nutrition.30:584–589
  30. C. C. Xu, S. F. Yang, L. H. Zhu, X. Cai, Y. S. Sheng, S. W. Zhu and J. X. Xu*.2014.Regulation of N-acetyl cysteine on gut redox status and major microbiota in weaned piglets. J ANIM SCI 92:1504-1511
  31. L. H. Zhu, J. X. Xu, S. W. Zhu, X. Cai, S. F. Yang, X. L. Chen and Q. Guo.2014. Gene expression profiling analysis reveals weaning-induced cell cycle arrest and apoptosis in the small intestine of pigs. J ANIM SCI 92 :996-1006
  32. X. L. Chen, L. Z. Gong and J. X. Xu*.2013. Antioxidative activity and protective effect of probiotics against high-fat diet-induced sperm damage in rats. Animal, 7: 287-292.  
  33. Xuan Cai, Xiaolian Chen,Xiaochun Wang,Congcong Xu,Qi Guo ,Lihui Zhu,Shuwen Zhu, Jianxiong Xu.2013.Pre-protective effect of lipoic acid on injury induced by H2O2 in IPEC-J2 cells 2013 Molecular and Cellular Biochemistry. 378:73-81
  34. Lihui Zhu, Xuan Cai1, Qi Guo, Xiaolian Chen, Suwen Zhu and Jianxiong Xu*.2013.Effectof N-acetylcysteine on enterocyte apoptosis and intracellular signalling pathways response to oxidative stress in weaned piglet. British Journal of Nutrition, 110, 1938–1947 

L. H. Zhu, K. L. Zhao, X. L. Chen and J. X. Xu* .2012. Impact of weaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs J. Anim. Sci. 90:2581–2589 

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